IGF1R Rabbit Polyclonal Antibody
CAT:
992-R1310-6
Size:
100 µL
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
IGF1R Rabbit Polyclonal Antibody
- Description: Type I insulin-like growth factor receptor (IGF-IR) is a transmembrane receptor tyrosine kinase that is widely expressed in many cell lines and cell types within fetal and postnatal tissues. The activated IGF1R is involved in cell growth and survival control. IGF1R is crucial for tumor transformation and survival of malignant cell. Ligand binding activates the receptor kinase, leading to receptor autophosphorylation, and tyrosines phosphorylation of multiple substrates, that function as signaling adapter proteins including, the insulin-receptor substrates (IRS1/2), Shc and 14-3-3 proteins. Phosphorylation of IRSs proteins lead to the activation of two main signaling pathways: the PI3K-AKT/PKB pathway and the Ras-MAPK pathway. The result of activating the MAPK pathway is increased cellular proliferation, whereas activating the PI3K pathway inhibits apoptosis and stimulates protein synthesis.
- Product Name Alternative: CD221 antibody CD221 antigen antibody IGF 1 receptor antibody IGF 1R antibody IGF I receptor antibody IGF-I receptor antibody Igf1r antibody IGF1R_HUMAN antibody IGFIR antibody IGFIRC antibody IGFR antibody Insulin like growth factor 1 receptor antibody Insulin like growth factor 1 receptor precursor antibody Insulin-like growth factor 1 receptor beta chain antibody Insulin-like growth factor I receptor antibody JTK13 antibody MGC142170 antibody MGC142172 antibody MGC18216 antibody Soluble IGF1R variant 1 antibody Soluble IGF1R variant 2 antibody
- Abbreviation: IGF-I receptor
- CAS Number: 9007-83-4
- Swiss Prot: P08069 Human
- Cellular Locus: Nucleus
- Host: Rabbit
- Species Reactivity: Human
- Immunogen: Recombinant protein with Human IGF1R aa 627-952 / 1,367.
- Isotype: IgG
- Conjugation: Non-conjugated
- Type: Rabbit polyclonal Antibody
- Applications: WB, IHC-P
- Positive Control: HepG2, SKOV-3, Hela, A549, 293T, human breast carcinoma tissue
- Concentration: 1 mg/mL
- Dilution: WB: 1:1,000 ;IHC-P: 1:100
- Purity: Protein A affinity purified.
- Form: Liquid
- Buffer: 1*PBS (pH7.4), 0.2% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
- Molecular Weight: ~95kDa
- Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
- Recombinant Antibody: No