HP1 alpha Mouse Monoclonal Antibody [B0-1]

• Description:

  Chromobox protein homolog 5 is a protein that in humans is encoded by the CBX5 gene. It is a highly conserved, non-histone protein part of the heterochromatin family. The protein itself is more commonly called (in humans) HP1α. Heterochromatin protein-1 (HP1) has an N-terminal domain that acts on methylated lysines residues leading to epigenetic repression. The C-terminal of this protein has a chromo shadow-domain (CSD) that is responsible for homodimerizing, as well as interacting with a variety of chromatin-associated, non-histone proteins. HP1α is a highly evolutionary conserved protein, existing in species such a Schizosaccharomyces pombe, a type of yeast, all the way to humans. The N-terminal chromodomain and C-terminal chromoshadow domain appear to be much more conserved (approximately 50-70% amino acid similarity) than the hinge region (approximately 25-30% similarity with the Drosophila HP1 homolog).

• Product Name Alternative:

  Antigen p25 antibody CBX5 antibody CBX5_HUMAN antibody CG8409 antibody Chromobox 5 antibody Chromobox homolog 5 (HP1 alpha homolog, Drosophila) antibody Chromobox homolog 5 antibody Chromobox protein homolog 5 antibody Epididymis luminal protein 25 antibody HEL25 antibody Heterochromatin protein 1 alpha antibody Heterochromatin protein 1 antibody Heterochromatin protein 1 homolog alpha antibody HP1 alpha antibody HP1 alpha homolog antibody HP1 antibody HP1A antibody HP1Hs alpha antibody Su (var)205 antibody

• Abbreviation:

  HP1 alpha

• Swiss Prot:

  P45973 Human, Q61686 Mouse,

• Cellular Locus:

  Nucleus

• Host:

  Mouse

• Species Reactivity:

  Human, Mouse, Rat

• Immunogen:

  Recombinant protein within Human HP1 alpha aa 1-191 / 191.

• Isotype:

  IgG1

• Conjugation:

  Non-conjugated

• Type:

  Mouse monoclonal Antibody

• Applications:

  WB, IF-Cell

• Positive Control:

  HeLa cell lysate, MCF7 cell lysate, NIH/3T3 cell lysate, RAW264.7 cell lysate, C6 cell lysate, PC-12 cell lysate, MCF7.

• Concentration:

  2 mg/mL

• Dilution:

  WB: 1:1,000 ;IF-Cell: 1:500

• Purity:

  Protein A affinity purified.

• Form:

  Liquid

• Buffer:

  1*PBS (pH7.4), 0.2% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

• Molecular Weight:

  Predicted band size: 22 kDa

• Storage Conditions:

  Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

• Recombinant Antibody:

  No

• CAS Number:

  9007-83-4