Complement C3 (beta chain) Mouse Monoclonal Antibody [11-10]

Complement C3 (beta chain) Mouse Monoclonal Antibody [11-10]

• Description: C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates. Derived from proteolytic degradation of complement C3, C3a anaphylatoxin is a mediator of local inflammatory process. In chronic inflammation, acts as a chemoattractant for neutrophils. It induces the contraction of smooth muscle, increases vascular permeability and causes histamine release from mast cells and basophilic leukocytes. Acts as a chemoattractant for neutrophils in chronic inflammation. Adipogenic hormone that stimulates triglyceride (TG) synthesis and glucose transport in adipocytes, regulating fat storage and playing a role in postprandial TG clearance. Appears to stimulate TG synthesis via activation of the PLC, MAPK and AKT signaling pathways. Ligand for C5AR2. Promotes the phosphorylation, ARRB2-mediated internalization and recycling of C5AR2. Plasma. The acylation stimulating protein (ASP) is expressed in adipocytes and released into the plasma during both the fasting and postprandial periods.
• Product Name Alternative: Acylation-stimulating protein cleavage product antibody AHUS5 antibody ARMD9 antibody ASP antibody C3 and PZP-like alpha-2-macroglobulin domain-containing protein 1 antibody C3 antibody CO3_HUMAN antibody Complement C3 antibody Complement C3 beta chain antibody Complement C3c alpha' chain fragment 2 antibody Complement component 3 antibody Complement component C3 antibody Complement factor 3 antibody CPAMD1 antibody Plp antibody
• Abbreviation: C3
• CAS Number: 9007-83-4
• Swiss Prot: P01024 Human
• Cellular Locus: Secreted
• Host: Mouse
• Species Reactivity: Human
• Immunogen: Synthetic peptide within human Complement C3 (β- chain) 480-560.
• Isotype: IgG2b
• Conjugation: Non-conjugated
• Type: Mouse monoclonal Antibody
• Applications: WB, IF-Cell, FC
• Positive Control: Human plasma
• Concentration: 2 mg/mL
• Dilution: WB: 1:2,000
• Purity: Protein A affinity purified.
• Form: Liquid
• Buffer: 1*PBS (pH7.4), 0.2% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
• Molecular Weight: 70kDa
• Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
• Recombinant Antibody: No