Complement C5 Recombinant Rabbit Monoclonal Antibody [PSH04-01]

• Description:

  Complement component 5 is a protein that in humans is encoded by the C5 gene. Complement component 5 is involved in the complement system. It is cleaved into C5a and C5b: C5a plays an important role in chemotaxis; C5b forms the first part of the complement membrane attack complex. Deficiency is thought to cause Leiner's disease. Complement component 5 is the fifth component of complement, which plays an important role in inflammatory and cell killing processes. This protein is composed of alpha and beta polypeptide chains that are linked by a disulfide bridge. An activation peptide, C5a, which is an anaphylatoxin that possesses potent spasmogenic and chemotactic activity, is derived from the alpha polypeptide via cleavage with a C5-convertase. The C5b macromolecular cleavage product can form a complex with the C6 complement component, and this complex is the basis for formation of the membrane attack complex, which includes additional complement components.

• Product Name Alternative:

  Complement C5 C3 and PZP-like alpha-2-macroglobulin domain-containing protein 4 Complement C5 beta chain Complement C5 alpha chain C5a anaphylatoxin Complement C5 alpha' chain C5 CPAMD4

• Abbreviation:

  C5, CPAMD4

• Swiss Prot:

  P01031 Human

• Cellular Locus:

  Secreted.

• Host:

  Rabbit

• Species Reactivity:

  Human

• Immunogen:

  Recombinant protein within human C5 aa 1-900 / 1,676.

• Isotype:

  IgG

• Clone:

  PSH04-01

• Conjugation:

  Non-conjugated

• Type:

  Recombinant Rabbit monoclonal Antibody

• Applications:

  WB, IF-Cell, IHC-P, FC

• Positive Control:

  HepG2 cell lysate, human liver tissue lysate, human plasma lysates, HepG2, human breast tissue, human liver tissue.

• Concentration:

  1 mg/mL

• Dilution:

  WB: 1:2,000 ;IF-Cell: 1:100 ;IHC-P: 1:200 ;FC: 1:1,000

• Purity:

  Protein A affinity purified.

• Form:

  Liquid

• Buffer:

  PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

• Molecular Weight:

  Predicted band size: 188 kDa

• Storage Conditions:

  Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.

• Recombinant Antibody:

  Yes

• CAS Number:

  9000-83-3