CD79a Recombinant Mouse Monoclonal Antibody [PDM0-23]

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CAT:

992-HA601118

Size:

100 µL

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CD79a Recombinant Mouse Monoclonal Antibody [PDM0-23]

Description: CD79a plays multiple and diverse roles in B cell development and function. The CD79a/b heterodimer associates non-covalently with the immunoglobulin heavy chain through its transmembrane region, thus forming the BCR along with the immunoglobulin light chain and the pre-BCR when associated with the surrogate light chain in developing B cells. Association of the CD79a/b heterodimer with the immunoglobulin heavy chain is required for surface expression of the BCR and BCR induced calcium flux and protein tyrosine phosphorylation. Genetic deletion of the transmembrane exon of CD79A results in loss of CD79a protein and a complete block of B cell development at the pro to pre B cell transition. Similarly, humans with homozygous splice variants in CD79A predicted to result in loss of the transmembrane region and a truncated or absent protein display agammaglobulinemia and no peripheral B cells. The CD79a ITAM tyrosines (human CD79a Tyr188 and Tyr199, mouse CD79a Tyr182 and Tyr193) phosphorylated in response to BCR crosslinking, are critical for binding of Src-homology 2 domain-containing kinases such as spleen tyrosine kinase (Syk) and signal transduction by CD79a. In vivo, the CD79a ITAM tyrosines synergize with the CD79b ITAM tyrosines to mediate the transition from the pro to the pre B cell stage as suggested by the analysis of mice with targeted mutations of the CD79a and CD79b ITAM. Loss of only one of the two functional CD79a/b ITAMs resulted in impaired B cell development but B cell functions such as the T cell independent type II response and BCR mediated calcium flux in the available B cells were intact. However, the presence of both the CD79a and CD79b ITAM tyrosines were required for normal T cell dependent antibody responses. The CD79a cytoplasmic domain further contains a non-ITAM tyrosine distal of the CD79a ITAM (human CD79a Tyr210, mouse CD79a Tyr204) that can bind BLNK and Nck once phosphorylated, and is critical for BCR mediated B cell proliferation and B1 cell development. CD79a ITAM tyrosine phosphorylation and signaling is negatively regulated by serine and threonine residues in direct proximity of the ITAM (human CD79a Ser197, Ser203, Thr209; mouse CD79a Ser191, Ser197, Thr203), and play a role in limiting formation of bone marrow plasma cells secreting IgG2a and IgG2b.
Alternative Name: B lymphocyte-specific MB1 protein antibody B-cell antigen receptor complex-associated protein alpha chain antibody CD 79a antibody CD79a antibody CD79a antigen (immunoglobulin-associated alpha) antibody CD79A antigen antibody CD79a molecule, immunoglobulin-associated alpha antibody CD79A_HUMAN antibody Ig alpha antibody Ig-alpha antibody IGA antibody IgM-alpha antibody Immunoglobulin-associated alpha antibody Ly54 antibody MB-1 membrane glycoprotein antibody MB1 antibody Membrane-bound immunoglobulin-associated protein antibody Surface IgM-associated protein antibody
Abbreviation: CD79A, IGA, MB1
Swiss Prot: P11912 Human
Cellular Locus: Cell membrane.
Host: Mouse
Species Reactivity: Human
Immunogen: Recombinant protein within human CD79a aa 33-143 (Extracellular).
Isotype: IgG1
Conjugation: Non-conjugated
Type: Recombinant Mouse monoclonal Antibody
Applications: WB, IHC-P
Positive Control: Human tonsil tissue, human appendix tissue, human lymph nodes tissue, Raji cell lysates.
Concentration: 2 mg/mL
Dilution: WB: 1:1,000 ;IHC-P: 1:200-1:1,000
Purity: Protein A affinity purified.
Form: Liquid
Buffer: PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight: Predicted band size: 25 kDa
Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody: Yes

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