GM-CSF Mouse Monoclonal Antibody [A6C6]

• Description:

  Granulocyte-macrophage colony-stimulating factor (GM-CSF), also known as colony-stimulating factor 2 (CSF2), is a monomeric glycoprotein secreted by macrophages, T cells, mast cells, natural killer cells, endothelial cells and fibroblasts that functions as a cytokine. Unlike granulocyte colony-stimulating factor, which specifically promotes neutrophil proliferation and maturation, GM-CSF affects more cell types, especially macrophages and eosinophils. GM-CSF is found in high levels in joints with rheumatoid arthritis and blocking GM-CSF as a biological target may reduce the inflammation or damage. Some drugs (e.g. otilimab) are being developed to block GM-CSF. In critically ill patients GM-CSF has been trialled as a therapy for the immunosuppression of critical illness, and has shown promise restoring monocyte and neutrophil function, although the impact on patient outcomes is currently unclear and awaits larger studies. GM-CSF stimulates monocytes and macrophages to produce pro-inflammatory cytokines, including CCL17. Elevated GM-CSF has been shown to contribute to inflammation in inflammatory arthritis, osteoarthritis, colitis asthma, obesity, and COVID-19.

• Product Name Alternative:

  Colony stimulating factor 2 (granulocyte-macrophage) antibody Colony Stimulating Factor 2 antibody Colony stimulating factor antibody Colony-stimulating factor antibody CSF 2 antibody CSF antibody CSF2 antibody CSF2_HUMAN antibody GM-CSF antibody GMCSF antibody Granulocyte Macrophage Colony Stimulating Factor antibody Granulocyte-macrophage colony-stimulating factor antibody MGC131935 antibody MGC138897 antibody MGI1GM antibody Molgramostin antibody Pluripoietin-a antibody Sargramostim antibody

• Abbreviation:

  CSF2

• Swiss Prot:

  P04141 Human

• Cellular Locus:

  Secreted.

• Host:

  Mouse

• Species Reactivity:

  Human

• Immunogen:

  Recombinant protein within Human GM-CSF aa 1-144/144.

• Isotype:

  IgG1

• Conjugation:

  Non-conjugated

• Type:

  Mouse monoclonal Antibody

• Applications:

  WB, ELISA

• Concentration:

  2 mg/mL

• Dilution:

  WB: 1:500 ;ELISA: 1:30,000

• Purity:

  Protein G affinity purified.

• Form:

  Liquid

• Buffer:

  PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

• Molecular Weight:

  Predicted band size: 16 kDa

• Storage Conditions:

  Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.

• Recombinant Antibody:

  No

• CAS Number:

  9007-83-4