ACVR2B Mouse Monoclonal Antibody [A5H6]

ACVR2B Mouse Monoclonal Antibody [A5H6]

• Description: Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Type II receptors are considered to be constitutively active kinases. This gene encodes activin A type IIB receptor, which displays a 3- to 4-fold higher affinity for the ligand than activin A type II receptor.
• Product Name Alternative: Activin A receptor type IIB antibody Activin receptor type 2B antibody Activin receptor type IIB antibody Activin receptor type-2B antibody ActR IIB antibody ACTR-IIB antibody ActRIIB antibody ACVR 2B antibody ACVR2B antibody AVR2B_HUMAN antibody HTX4 antibody MGC116908 antibody
• Abbreviation: ACVR2B
• CAS Number: 9007-83-4
• Swiss Prot: Q13705 Human, P27040 Mouse, P38445 Rat, Q9YGU4 Zebrafish
• Cellular Locus: Cell membrane.
• Host: Mouse
• Species Reactivity: Human, Mouse, Rat, Zebrafish
• Immunogen: Synthetic peptide within human ACVR2B aa 331-380 / 512.
• Isotype: IgG2a
• Conjugation: Non-conjugated
• Type: Mouse monoclonal Antibody
• Applications: WB
• Positive Control: Hela cell lysates.
• Concentration: 2 mg/mL
• Dilution: WB: 1:500-1:2,000
• Purity: Protein G affinity purified.
• Form: Liquid
• Buffer: 1*TBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
• Molecular Weight: 58 kDa
• Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
• Recombinant Antibody: No