Activin Receptor Type IIB / ACVR2B Recombinant Rabbit Monoclonal Antibody [JE33-52]

Activin Receptor Type IIB / ACVR2B Recombinant Rabbit Monoclonal Antibody [JE33-52]

• Description: Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Type II receptors are considered to be constitutively active kinases. This gene encodes activin A type IIB receptor, which displays a 3- to 4-fold higher affinity for the ligand than activin A type II receptor.
• Product Name Alternative: Activin A receptor type IIB antibody Activin receptor type 2B antibody Activin receptor type IIB antibody Activin receptor type-2B antibody ActR IIB antibody ACTR-IIB antibody ActRIIB antibody ACVR 2B antibody ACVR2B antibody AVR2B_HUMAN antibody HTX4 antibody MGC116908 antibody
• Abbreviation: ACVR2B
• CAS Number: 9000-83-3
• Swiss Prot: Q13705 Human, P27040 Mouse, P38445 Rat
• Cellular Locus: Cell membrane.
• Host: Rabbit
• Species Reactivity: Human, Mouse, Rat
• Immunogen: Recombinant protein within
• Isotype: IgG
• Clone: JE33-52
• Conjugation: Non-conjugated
• Type: Recombinant Rabbit monoclonal Antibody
• Applications: WB
• Positive Control: 293T cell lysate, K-562 cell lysate, Jurkat cell lysate, HeLa cell lysate, Mouse heart tissue lysate, Rat heart tissue lysate.
• Concentration: 1 mg/mL
• Dilution: WB: 1:1,000
• Purity: Protein A affinity purified.
• Form: Liquid
• Buffer: 1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
• Molecular Weight: Predicted band size: 58 kDa
• Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
• Recombinant Antibody: Yes