CD47 Mouse Monoclonal Antibody [1A9]

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CAT:

992-EM1701-38

Size:

100 µL

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CD47 Mouse Monoclonal Antibody [1A9]

Description: CD47 is an integral membrane protein that plays a role in the regulation of cation fluxes across cell membranes. Specifically, CD47 is involved in the increase in intracellular calcium concentration that occurs upon cell adhesion to the extracellular matrix. It is also a receptor for the C-terminal cell binding domain of thrombospondin (SIRP). Has a role in both cell adhesion by acting as an adhesion receptor for THBS1 on platelets, and in the modulation of integrins. CD47 is absent from Rh-null erythrocytes, but does play a role in cell adhesion in non-erythroid cells and may prevent premature elimination of erythrocytes. It may also be involved in membrane permeability changes following viral infection. Plays an important role in memory formation and synaptic plasticity in the hippocampus (By similarity). Receptor for SIRPA, binding to which prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells. Interaction with SIRPG mediates cell-cell adhesion, enhances superantigen-dependent T-cell-mediated proliferation and costimulates T-cell activation. May play a role in membrane transport and/or integrin dependent signal transduction. May prevent premature elimination of red blood cells. May be involved in membrane permeability changes induced following virus infection. CD47 is expressed on hemopoietic cells, epithelial cells, endothelial cells and fibroblasts and is strongly expressed in brain and mesenchymal cells.
Alternative Name: Antigen identified by monoclonal antibody 1D8 antibody Antigenic surface determinant protein OA3 antibody CD 47 antibody Cd47 antibody CD47 antigen (Rh-related antigen, integrin-associated signal transducer) antibody CD47 antigen antibody CD47 glycoprotein antibody CD47 molecule antibody CD47_HUMAN antibody IAP antibody Integrin Associated Protein antibody Integrin associated signal transducer antibody Integrin-associated protein antibody Leukocyte surface antigen CD47 antibody MER 6 antibody MER6 antibody OA 3 antibody OA3 antibody OTTHUMP00000041152 antibody OTTHUMP00000041153 antibody Protein MER6 antibody Rh related antigen antibody Surface antigen identified by monoclonal antibody 1D8 antibody
Abbreviation: IAP, CD47, MER6
Swiss Prot: Q08722 Human
Cellular Locus: Cell membrane, Multi-pass membrane protein.
Host: Mouse
Species Reactivity: Human
Immunogen: Recombinant protein within Human CD47 aa 19-141 (Extracellular).
Isotype: IgM
Conjugation: Non-conjugated
Type: Mouse monoclonal Antibody
Applications: IF-Cell, IHC-P, FC
Positive Control: Human ovarian carcinoma tissue, human prostate tissue, SH-SY5Y.
Concentration: 2 mg/mL
Dilution: IF-Cell: 1:50-1:100;IHC-P: 1:200-1,000;FC: 1:50-1:100
Purity: Protein G affinity purified.
Form: Liquid
Buffer: 1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight: Predicted band size: 35 kDa
Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Recombinant Antibody: No

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