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RNF111 Rabbit Polyclonal Antibody

CAT: 0992-HA500485Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0992-HA500485Size:100 µL
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Description
E3 ubiquitin-protein ligase. Required for mesoderm patterning during embryonic development. Acts as an enhancer of the transcriptional responses of the SMAD2/SMAD3 effectors, which are activated downstream of BMP. Acts by mediating ubiquitination and degradation of SMAD inhibitors such as SMAD7, inducing their proteasomal degradation and thereby enhancing the transcriptional activity of TGF-beta and BMP. In addition to enhance transcription of SMAD2/SMAD3 effectors, also regulates their turnover by mediating their ubiquitination and subsequent degradation, coupling their activation with degradation, thereby ensuring that only effectors 'in use' are degraded. Activates SMAD3/SMAD4-dependent transcription by triggering signal-induced degradation of SNON isoform of SKIL. Associates with UBE2D2 as an E2 enzyme. Specifically binds polysumoylated chains via SUMO interaction motifs (SIMs) and mediates ubiquitination of sumoylated substrates. Catalyzes 'Lys-63'-linked ubiquitination of sumoylated XPC in response to UV irradiation, promoting nucleotide excision repair. Mediates ubiquitination and degradation of sumoylated PML. The regulation of the BMP-SMAD signaling is however independent of sumoylation and is not dependent of SUMO interaction motifs (SIMs).
CAS Number
9007-83-4
Product Name Alternative
BCA2 antibody Breast cancer associated gene 2 antibody CL469780 antibody E3 ubiquitin-protein ligase RNF115 antibody Rabring 7 antibody RING finger protein 115 antibody RN115_HUMAN antibody RNF115 antibody Zinc finger protein 364 antibody ZNF364 antibody
Abbreviation
RNF111
Swiss Prot
Q6ZNA4 Human
Cellular Locus
Cytoplasm, Nucleus, PML body.
Host
Rabbit
Species Reactivity
Human
Immunogen
Recombinant protein within human RNF111 aa 795-994 / 994.
Isotype
IgG
Conjugation
Non-conjugated
Type
Rabbit polyclonal Antibody
Applications
WB, IHC-P, FC
Positive Control
K562 cell lysate, 293T cell lysate, Hela cell lysate, human placenta tissue, Hela.
Concentration
1 mg/mL
Dilution
WB: 1:500-1:2,000 ;IHC-P: 1:50-1:200 ;FC: 1:500-1:1,000
Purity
Immunogen affinity purified.
Form
Liquid
Buffer
1*TBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight
109 kDa
Storage Conditions
Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody
No

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