Sall4 Rabbit Polyclonal Antibody

Sal-like protein 4 (SALL4) is a transcription factor encoded by a member of the Spalt-like (SALL) gene family, SALL4. The SALL genes were identified based on their sequence homology to Spalt, which is a homeotic gene originally cloned in Drosophila melanogaster that is important for terminal trunk structure formation in embryogenesis and imaginal disc development in the larval stages.[7][8] There are four human SALL proteins (SALL1, 2, 3, and 4) with structural homology and playing diverse roles in embryonic development, kidney function, and cancer.[9] The SALL4 gene encodes at least three isoforms, termed A, B, and C, through alternative splicing, with the A and B forms being the most studied. SALL4 can alter gene expression changes through its interaction with many co-factors and epigenetic complexes. It is also known as a key embryonic stem cell (ESC) factor. The various SALL4-null mouse models mimic human mutations in the SALL4 gene, which were shown to cause developmental problems in patients with Okihiro/Duane-Radial-ray syndrome. SALL4 expression is low to undetectable in most adult tissues with the exception of germ cells and human blood progenitor cells. In breast cancer, Signal transducer and activator of transcription 3 (STAT3) has been reported to directly activate SALL4 expression.

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AA407717 antibody AL022809 antibody AW536104 antibody C330011P20Rik antibody C78083 antibody C78563 antibody dJ1112F19.1 antibody DRRS antibody HSAL4 antibody Sal like 4 (Drosophila) antibody Sal like 4 antibody Sal like Protein 4 antibody Sal-like protein 4 antibody Sall4 antibody SALL4_HUMAN antibody Spalt like transcription factor 4 antibody Tex20 antibody Zinc finger protein 797 antibody Zinc finger protein SALL4 antibody ZNF797 antibody

SALL4

Q9UJQ4 Human

Nucleus, Cytoplasm.

Recombinant protein within human Sall4 aa 1-200 / 1,053.

Non-conjugated

Rabbit polyclonal Antibody

WB, IHC-P

CAL-62 cell lysates, human seminoma tissue.

1 mg/mL

WB: 1:500-1:2,000 ;IHC-P: 1:200-1:1,000

Immunogen affinity purified.

Liquid

1*TBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.

112 kDa

Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.