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BCL9L Rabbit Polyclonal Antibody

CAT: 0992-HA500459Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0992-HA500459Size:100 µL
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Description
Transcriptional regulator that acts as an activator. Promotes beta-catenin transcriptional activity. Plays a role in tumorigenesis. Enhances the neoplastic transforming activity of CTNNB1. In mammalian cells, BCL9 proteins contribute to, but may not be obligatory for, β-catenin–mediated transcription. BCL9L mRNA knockdown in a human colon cancer cell line induced an epithelial phenotype that was associated with the translocation of β-catenin from the nucleus to the cell membrane, suggesting that BCL9L might regulate the switch between the adhesive and transcriptional functions of β-catenin. BCL9L upregulation has been associated with breast and colon cancers, and BCL9 has recently been reported to enhance β-catenin–mediated transcription and increase the proliferation as well as the metastatic potential of tumor cells.
CAS Number
9007-83-4
Product Name Alternative
B-cell CLL antibody B-cell CLL/lymphoma 9-like protein antibody B-cell lymphoma 9-like protein antibody B9L antibody BCL9-2 antibody BCL9-like protein antibody BCL9-related beta-catenin-binding protein antibody Bcl9l antibody BCL9L_HUMAN antibody DLNB11 antibody Nuclear co factor of beta catenin signalling antibody Protein BCL9-2 antibody
Abbreviation
BCL9L, DLNB11
Swiss Prot
Q86UU0 Human, Q67FY2 Mouse,
Cellular Locus
Nucleus.
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Immunogen
Recombinant protein within Human BCL9L aa 351-550 / 1,499.
Isotype
IgG
Conjugation
Non-conjugated
Type
Rabbit polyclonal Antibody
Applications
WB, IHC-P
Positive Control
Rat skin tissue, mouse skin tissue, human lung carcinoma tissue, human liver tissue, Hela cell lysate, MCF-7 cell lysate, NIH/3T3 cell lysate.
Concentration
1.861 mg/mL
Dilution
WB: 1:1,000 ;IHC-P: 1:1,000
Purity
Immunogen affinity purified.
Form
Liquid
Buffer
PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight
Predicted band size: 157 kDa
Storage Conditions
Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody
No