RSPO2 Rabbit Polyclonal Antibody

RSPO2 Rabbit Polyclonal Antibody

• Description: R-spondin 2 also known as roof plate-specific spondin-2 is a secreted protein that in humans that is encoded by the RSPO2 gene. R-spondin 2 synergizes with canonical WNT to activate beta-catenin. RSPO2 has been proposed to regulate craniofacial patterning and morphogenesis within pharyngeal arch 1 through ectoderm-mesenchyme signaling via the endothelin-Dlx5/6 pathway. In dogs, a variant on the Rspo2 gene is associated moustache and eyebrow thickness. In humans, recessive mutations in RSPO2 abrogate limb and lung development. Bruno Reversade and colleagues have reported in 2018 that loss of RSPO2 results in a syndrome of Tetra-amelia with lung agenesis.
• Product Name Alternative: RSPO2 UNQ9384/PRO34209 Roof plate-specific spondin-2 (hRspo2) R-spondin-2
• Abbreviation: RSPO2
• CAS Number: 9007-83-4
• Swiss Prot: Q6UXX9 Human, Q8BFU0 Mouse,
• Cellular Locus: Secreted.
• Host: Rabbit
• Species Reactivity: Human, Mouse, Rat
• Immunogen: Synthetic peptide within human RSPO2 aa 51-100 / 243.
• Isotype: IgG
• Conjugation: Non-conjugated
• Type: Rabbit polyclonal Antibody
• Applications: WB, IHC-P
• Positive Control: 293 cell lysate, human lung tissue lysate, mouse brain tissue lysate, rat brain tissue lysate, human kidney tissue, mouse small intestine tissue.
• Concentration: 5.17 mg/mL
• Dilution: WB: 1:1,000 ;IHC-P: 1:500-1:1,000
• Purity: Protein A affinity purified.
• Form: Liquid
• Buffer: PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
• Molecular Weight: Predicted band size: 28 kDa
• Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
• Recombinant Antibody: No