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EGR4 Rabbit Polyclonal Antibody

CAT: 0992-HA500445Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0992-HA500445Size:100 µL
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Description
Early growth response protein 4 (EGR-4), also known as AT133, is a protein that in humans is encoded by the EGR4 gene. EGR-4 is a member of the early growth response (EGF) family of zinc finger transcription factors. Transcription factors EGR1, 2, and 3 also share an R1 domain, missing in EGR4, which can be bound by NAB proteins to prevent expression of EGR target genes. The EGR zinc finger motifs are designed to specifically recognize a 9 base pair consensus sequence (5′ GCG TGG GCG 3′), with each finger spanning three nucleotides. A loss of Egr4 results in a block in spermatogenesis at the early-mid pachytene spermatocyte stage leading to a significant reduction in the number of spermatozoa produced. Additionally, Erg4-null spermatozoa show abnormal morphology such as separated heads and fragmented flagellum. The block also occurred during the first wave of spermatogenesis as apoptotic germ cells were present from 14 dpp onward. The importance of EGR4 for fertility in mammals has also been demonstrated in human males with cryptorchidism.
CAS Number
9007-83-4
Product Name Alternative
AT133 antibody Early growth response protein 4 antibody Nerve growth factor induced clone C antibody NGFI C antibody NGFIC antibody PAT133 antibody Egr4
Abbreviation
Egr4
Swiss Prot
Q05215 Human, Q9WUF2 Mouse, Q00911 Rat
Cellular Locus
Nucleus.
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Immunogen
Recombinant protein within mouse EGR4 aa 300-478 / 589.
Isotype
IgG
Conjugation
Non-conjugated
Type
Rabbit polyclonal Antibody
Applications
IHC-P
Positive Control
Rat brain tissue, human colon tissue, mouse brain tissue.
Concentration
1 mg/mL
Dilution
IHC-P:1:50-1:200
Purity
Protein A affinity purified.
Form
Liquid
Buffer
1*TBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight
50 kDa
Storage Conditions
Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody
No

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