TRRAP Rabbit Polyclonal Antibody

• Description:

  Adapter protein, which is found in various multiprotein chromatin complexes with histone acetyltransferase activity (HAT), which gives a specific tag for epigenetic transcription activation. Component of the NuA4 histone acetyltransferase complex which is responsible for acetylation of nucleosomal histones H4 and H2A. Plays a central role in MYC transcription activation, and also participates in cell transformation by MYC. Required for p53/TP53-, E2F1- and E2F4-mediated transcription activation. Also involved in transcription activation mediated by the adenovirus E1A, a viral oncoprotein that deregulates transcription of key genes. Probably acts by linking transcription factors such as E1A, MYC or E2F1 to HAT complexes such as STAGA thereby allowing transcription activation. Probably not required in the steps following histone acetylation in processes of transcription activation. May be required for the mitotic checkpoint and normal cell cycle progression. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AZ1 from the nucleosome. May play a role in the formation and maintenance of the auditory system (By similarity).

• Product Name Alternative:

  350/400 kDa PCAF associated factor antibody PAF 350/400 antibody PAF 400 antibody PAF350/400 antibody PAF400 antibody STAF 40 antibody STAF40 antibody TR AP antibody Tra 1 antibody Tra1 antibody Tra1 homolog antibody Transactivation / transformation domain associated protein antibody Transactivation/transformation domain associated protein antibody Transformation/transcription domain associated protein antibody TRAP antibody

• Abbreviation:

  TRRAP

• Swiss Prot:

  Q9Y4A5 Human, Q80YV3 Mouse, A0A8I5Y6J8 Rat

• Cellular Locus:

  Nucleus.

• Host:

  Rabbit

• Species Reactivity:

  Human, Mouse, Rat

• Immunogen:

  Recombinant protein within Human TRRAP aa 2,601-2,910 / 3,859.

• Isotype:

  IgG

• Conjugation:

  Non-conjugated

• Type:

  Rabbit polyclonal Antibody

• Applications:

  WB, IHC-P

• Positive Control:

  K-562 cell lysate, 293T cell lysate, PC-12 cell lysate, L6 cell lysate, PMVEC cell lysate, rat brain tissue.

• Concentration:

  0.6795 mg/mL

• Dilution:

  WB: 1:1,000 ;IHC-P: 1:600

• Purity:

  Immunogen affinity purified.

• Form:

  Liquid

• Buffer:

  PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

• Molecular Weight:

  Predicted band size: 438kDa

• Storage Conditions:

  Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.

• Recombinant Antibody:

  No

• CAS Number:

  9007-83-4