RYK Rabbit Polyclonal Antibody

The protein encoded by this gene is an atypical member of the family of growth factor receptor protein tyrosine kinases, differing from other members at a number of conserved residues in the activation and nucleotide binding domains. This gene product belongs to a subfamily whose members do not appear to be regulated by phosphorylation in the activation segment. It has been suggested that mediation of biological activity by recruitment of a signaling-competent auxiliary protein may occur through an as yet uncharacterized mechanism. The encoded protein has a leucine-rich extracellular domain with a WIF-type Wnt binding region, a single transmembrane domain, and an intracellular tyrosine kinase domain. This protein is involved in stimulating Wnt signaling pathways such as the regulation of axon pathfinding. Alternative splicing results in multiple transcript variants encoding distinct isoforms. May be a coreceptor along with FZD8 of Wnt proteins, such as WNT1, WNT3, WNT3A and WNT5A. Involved in neuron differentiation, axon guidance, corpus callosum establishment and neurite outgrowth. In response to WNT3 stimulation, receptor C-terminal cleavage occurs in its transmembrane region and allows the C-terminal intracellular product to translocate from the cytoplasm to the nucleus where it plays a crucial role in neuronal development.

9007-83-4

D3S3195 antibody ERK 3 antibody Hydroxyaryl protein kinase antibody JTK 5 antibody JTK 5A antibody JTK5 antibody JTK5A antibody JTK5A protein tyrosine kinase antibody receptor like tyrosine kinase antibody receptor like tyrosine kinase precursor antibody RYK 1 antibody Ryk antibody RYK_HUMAN antibody RYK1 antibody Tyrosine protein kinase RYK antibody Tyrosine protein kinase RYK precursor antibody Tyrosine-protein kinase RYK antibody Vik antibody

Tyrosine-protein kinase RYK RYK JTK5A

P34925 Human, Q01887 Mouse,

Cytoplasm, Membrane, Nucleus.

Recombinant protein within human RYK aa 300-550.

Non-conjugated

Rabbit polyclonal Antibody

WB, IF-Cell, FC

SH-SY5Y cell lysate, NIH/3T3 cell lysate, mouse brain tissue lysate, rat brain tissue lysate, MCF-7 cell lysates, NIH/3T3, SH-SY5Y.

1.777 mg/mL

WB: 1:500-1:10,000;IF-Cell: 1:200;FC: 1:500-1:1,000

Immunogen affinity purified.

Liquid

PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Predicted band size: 68 kDa

Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.