RBBP5 Rabbit Polyclonal Antibody

• Description:

  In embryonic stem (ES) cells, plays a crucial role in the differentiation potential, particularly along the neural lineage, regulating gene induction and H3 'Lys-4' methylation at key developmental loci, including that mediated by retinoic acid. Does not affect ES cell self-renewal. Component or associated component of some histone methyltransferase complexes which regulates transcription through recruitment of those complexes to gene promoters. As part of the MLL1/MLL complex, involved in mono-, di- and trimethylation at 'Lys-4' of histone H3. Histone H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. In association with ASH2L and WDR5, stimulates the histone methyltransferase activities of KMT2A, KMT2B, KMT2C, KMT2D, SETD1A and SETD1B.

• Product Name Alternative:

  RBBP 5 antibody RBBP-5 antibody RBBP5 antibody RBBP5_HUMAN antibody RBQ 3 antibody RBQ3 antibody Retinoblastoma binding protein 5 antibody Retinoblastoma binding protein RBQ3 antibody Retinoblastoma binding protein5 antibody Retinoblastoma-binding protein 5 antibody Retinoblastoma-binding protein RBQ-3 antibody SWD1 antibody SWD1, Set1c WD40 repeat protein, homolog antibody

• Abbreviation:

  Retinoblastoma-binding protein 5 RBBP-5 Retinoblastoma-binding protein RBQ-3 RBBP5 RBQ3

• Swiss Prot:

  Q15291 Human, Q8BX09 Mouse

• Cellular Locus:

  Nucleus.

• Host:

  Rabbit

• Species Reactivity:

  Human

• Immunogen:

  Synthetic peptide within human RBBP5 aa 1-50.

• Isotype:

  IgG

• Conjugation:

  Non-conjugated

• Type:

  Rabbit polyclonal Antibody

• Applications:

  WB, IHC-P

• Positive Control:

  293 cell lysate, MCF-7 cell lysate, human lung carcinoma tissue, human colon tissue.

• Concentration:

  2.1 mg/mL

• Dilution:

  WB: 1:500

• Purity:

  Immunogen affinity purified.

• Form:

  Liquid

• Buffer:

  PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

• Molecular Weight:

  Predicted band size: 59 kDa

• Storage Conditions:

  Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.

• Recombinant Antibody:

  No

• CAS Number:

  9007-83-4