IL23R Rabbit Polyclonal Antibody

The interleukin-23 receptor is a type I cytokine receptor. It is encoded in human by the IL23R gene. In complex with the interleukin-12 receptor β1 subunit (IL-12Rβ1), it is activated by the cytokine interleukin 23 (IL-23). The IL23R mRNA is 2.8 kilobases in length and includes 12 exons. The translated protein contains 629 amino acids; it is a type I penetrating protein and includes a signal peptide, an N-terminal fibronectin III-like domain and an intracellular part that contains three potential tyrosine phosphorylation domains. There are 24 IL23R splice variants in mitogen-activated lymphocytes. IL23R includes some single-nucleotide polymorphisms in the region encoding the domain that binds IL-23, which may lead to differences between people in Th17 activation. There is also a variant of IL-23R that consists of just the extracellular part and is known as soluble IL-23R. This form can compete with the membrane-bound form to bind IL-23, modulating the Th17 immune response and regulation of inflammation and immune function. The protein encoded by this gene is a subunit of the receptor for IL-23. This protein pairs with the receptor molecule IL-12Rβ1 (IL12RB1), together forming the IL-23 receptor complex, and both are required for IL-23 signaling. This protein associates constitutively with Janus kinase 2 (JAK2) and also binds to transcription activator STAT3 in a ligand-dependent manner. Three variants in the IL23R gene have been shown to protect against Crohn's disease and ulcerative colitis. The effect of IL-23R variations present in the population have been studied with an in vitro expression model system.

9007-83-4

IL 23R antibody IL-23 receptor antibody IL-23R antibody IL23 Receptor antibody Il23r antibody IL23R_HUMAN antibody Interleukin 23 receptor antibody Interleukin-23 receptor antibody

Interleukin-23 receptor IL-23 receptor IL-23R IL23R

Q5VWK5 Human

Cell membrane.

Synthetic peptide within human IL23R aa 440-490.

Non-conjugated

Rabbit polyclonal Antibody

WB, IF-Cell

MCF-7 cell lysate, 293 cell lysate, SH-SY5Y.

1.88 mg/mL

WB: 1:500;IF-Cell: 1:200

Immunogen affinity purified.

Liquid

PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Predicted band size: 72 kDa

Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.