PGBD5 Rabbit Polyclonal Antibody

• Description:

  PiggyBac Transposable Element Derived 5 is an enzyme that in humans is encoded by the PGBD5 gene. The putative catalytic triad of the protein composed of three aspartic acid residues is conserved among PGBD5-like genes through evolution, and is distinct from other PiggyBac-like genes. PGBD5 has been shown to be able to transpose DNA in a sequence-specific, cut-and-paste fashion. PGBD5 has also been proposed to mediate site-specific DNA rearrangements in human tumors. Human PGBD5 can mobilize the insect PiggyBac transposons in human cell culture. In mature mice brain tissue PGBD5 is found primarily in regions of the olfactory bulb, hippocampus, and cerebellum. In embryonic mice brain tissue PGBD5 is found not only in the medial pallium and prepontine isthmus, which are embryonic brain areas that give rise to the development of the hippocampus and cerebellum but also in areas in the embryonic brain that give rise to the hypothalamus and medulla. PGBD5 is expressed in the majority of human pediatric solid tumors. It's upregulated in sporadic Creutzfeldt-Jakob disease. PGBD5 is associated with frontotemporal dementia, where it gets most expressed in neurons, followed by ogliodendrocytes, mature astrocytes, fetal astrocytes, endothelial cells and then microglia/macrophages.

• Product Name Alternative:

  PGBD5 antibody PGBD5_HUMAN antibody PiggyBac transposable element-derived protein 5 antibody

• Abbreviation:

  PiggyBac transposable element-derived protein 5 PiggyBac domain-related protein 5 PiggyBac transposase 5 PGBD5

• Swiss Prot:

  Q8N414 Human, D3YZI9 Mouse, D3ZSZ4 Rat

• Cellular Locus:

  Nucleus.

• Host:

  Rabbit

• Species Reactivity:

  Human, Mouse, Rat

• Immunogen:

  Recombinant protein within human PGBD5 aa 270-520.

• Isotype:

  IgG

• Conjugation:

  Non-conjugated

• Type:

  Rabbit polyclonal Antibody

• Applications:

  WB, IHC-P

• Positive Control:

  Daudi cell lysates, human lung carcinoma tissue, mouse uterus tissue.

• Concentration:

  2.1 mg/mL

• Dilution:

  WB: 1:1,000 ;IHC-P: 1:1,000

• Purity:

  Immunogen affinity purified.

• Form:

  Liquid

• Buffer:

  PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

• Molecular Weight:

  Predicted band size: 58 kDa

• Storage Conditions:

  Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.

• Recombinant Antibody:

  No

• CAS Number:

  9007-83-4