IFNGR2 Rabbit Polyclonal Antibody

• Description:

  Interferon gamma receptor 2 also known as IFN-γR2 is a protein which in humans is encoded by the IFNGR2 gene. This gene (IFNGR2) encodes the non-ligand-binding beta chain of the gamma interferon receptor. Human interferon-gamma receptor is a multimer of two IFN-γR1 chains (encoded by IFNGR1) and two IFN-γR2 chains. Associates with IFNGR1 to form a receptor for the cytokine interferon gamma (IFNG). Ligand binding stimulates activation of the JAK/STAT signaling pathway. Required for signal transduction in contrast to other receptor subunit responsible for ligand binding. Defects in IFNGR2 are a cause of autosomal recessive mendelian susceptibility to mycobacterial disease (MSMD), also known as familial disseminated atypical mycobacterial infection. All known mutations in IFNGR2 are collected in the IFNGR2 mutation database.

• Product Name Alternative:

  Interferon gamma receptor 2Imported antibody IFN-gamma receptor 2 antibody IFN-gamma-R2 antibody Interferon gamma receptor accessory factor 1 antibody AF-1 antibody Interferon gamma receptor beta-chain antibody IFN-gamma-R-beta antibody Interferon gamma transducer 1 antibody IFNGR2 antibody IFNGT1 antibody

• Abbreviation:

  Interferon gamma receptor 2Imported IFN-gamma receptor 2 IFN-gamma-R2 Interferon gamma receptor accessory factor 1 AF-1 Interferon gamma receptor beta-chain IFN-gamma-R-beta Interferon gamma transducer 1 IFNGR2 IFNGT1

• CAS Number:

  9007-83-4

• Swiss Prot:

  P38484 Human,

• Cellular Locus:

  Endoplasmic reticulum, Plasma membrane, Golgi apparatus.

• Host:

  Rabbit

• Species Reactivity:

  Human, Mouse, Rat

• Immunogen:

  Synthetic peptide within human INGR2 22-71.

• Isotype:

  IgG

• Conjugation:

  Non-conjugated

• Type:

  Rabbit polyclonal Antibody

• Applications:

  WB, IF-Cell

• Positive Control:

  Jurkat cell lysate, Hela cell lysate, A431 cell lysate, human skeletal muscle tissue lysates, SH-SY5Y.

• Concentration:

  1.8 mg/mL

• Dilution:

  WB: 1:500 ;IF-Cell: 1:200

• Purity:

  Immunogen affinity purified.

• Form:

  Liquid

• Buffer:

  PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

• Molecular Weight:

  Predicted band size: 38 kDa

• Storage Conditions:

  Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.

• Recombinant Antibody:

  No