PERK Rabbit Polyclonal Antibody
CAT:
992-HA500326
Size:
100 µL
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
PERK Rabbit Polyclonal Antibody
- Description: Metabolic-stress sensing protein kinase that phosphorylates the alpha subunit of eukaryotic translation initiation factor 2 (EIF2S1/eIF-2-alpha) in response to various stress conditions. Key activator of the integrated stress response (ISR) required for adaptation to various stress, such as unfolded protein response (UPR) and low amino acid availability. EIF2S1/eIF-2-alpha phosphorylation in response to stress converts EIF2S1/eIF-2-alpha in a global protein synthesis inhibitor, leading to a global attenuation of cap-dependent translation, while concomitantly initiating the preferential translation of ISR-specific mRNAs, such as the transcriptional activators ATF4 and QRICH1, and hence allowing ATF4- and QRICH1-mediated reprogramming. Serves as a critical effector of unfolded protein response (UPR)-induced G1 growth arrest due to the loss of cyclin-D1 (CCND1). Involved in control of mitochondrial morphology and function.
- Product Name Alternative: DKFZp781H1925 antibody E2AK3_HUMAN antibody EC 2.7.11.1 antibody Eif2ak3 antibody Eukaryotic translation initiation factor 2 alpha kinase 3 antibody Eukaryotic translation initiation factor 2-alpha kinase 3 antibody Heme regulated EIF2 alpha kinase antibody HRI antibody HsPEK antibody Pancreatic eIF2 alpha kinase antibody Pancreatic eIF2-alpha kinase antibody PEK antibody PRKR like endoplasmic reticulum kinase antibody PRKR-like endoplasmic reticulum kinase antibody WRS antibody
- Abbreviation: EIF2AK3
- CAS Number: 9007-83-4
- Swiss Prot: Q9NZJ5 Human
- Cellular Locus: Endoplasmic reticulum membrane.
- Host: Rabbit
- Species Reactivity: Human
- Immunogen: Synthetic peptide within human PERK aa 1,067-1,116/1,116.
- Isotype: IgG
- Conjugation: Non-conjugated
- Type: Rabbit polyclonal Antibody
- Applications: WB
- Positive Control: MCF-7 cell lysate, 293 cell lysate, HepG2 cell lysate, Hela cell lysate.
- Concentration: 1 mg/mL
- Dilution: WB: 1:1,000
- Purity: Immunogen affinity purified.
- Form: Liquid
- Buffer: PBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
- Molecular Weight: Predicted band size: 125 kDa
- Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
- Recombinant Antibody: No