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PERK Rabbit Polyclonal Antibody

CAT: 0992-HA500326Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0992-HA500326Size:100 µL
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Description
Metabolic-stress sensing protein kinase that phosphorylates the alpha subunit of eukaryotic translation initiation factor 2 (EIF2S1/eIF-2-alpha) in response to various stress conditions. Key activator of the integrated stress response (ISR) required for adaptation to various stress, such as unfolded protein response (UPR) and low amino acid availability. EIF2S1/eIF-2-alpha phosphorylation in response to stress converts EIF2S1/eIF-2-alpha in a global protein synthesis inhibitor, leading to a global attenuation of cap-dependent translation, while concomitantly initiating the preferential translation of ISR-specific mRNAs, such as the transcriptional activators ATF4 and QRICH1, and hence allowing ATF4- and QRICH1-mediated reprogramming. Serves as a critical effector of unfolded protein response (UPR)-induced G1 growth arrest due to the loss of cyclin-D1 (CCND1). Involved in control of mitochondrial morphology and function.
CAS Number
9007-83-4
Product Name Alternative
DKFZp781H1925 antibody E2AK3_HUMAN antibody EC 2.7.11.1 antibody Eif2ak3 antibody Eukaryotic translation initiation factor 2 alpha kinase 3 antibody Eukaryotic translation initiation factor 2-alpha kinase 3 antibody Heme regulated EIF2 alpha kinase antibody HRI antibody HsPEK antibody Pancreatic eIF2 alpha kinase antibody Pancreatic eIF2-alpha kinase antibody PEK antibody PRKR like endoplasmic reticulum kinase antibody PRKR-like endoplasmic reticulum kinase antibody WRS antibody
Abbreviation
EIF2AK3
Swiss Prot
Q9NZJ5 Human
Cellular Locus
Endoplasmic reticulum membrane.
Host
Rabbit
Species Reactivity
Human
Immunogen
Synthetic peptide within human PERK aa 1,067-1,116/1,116.
Isotype
IgG
Conjugation
Non-conjugated
Type
Rabbit polyclonal Antibody
Applications
WB
Positive Control
MCF-7 cell lysate, 293 cell lysate, HepG2 cell lysate, Hela cell lysate.
Concentration
1 mg/mL
Dilution
WB: 1:1,000
Purity
Immunogen affinity purified.
Form
Liquid
Buffer
PBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight
Predicted band size: 125 kDa
Storage Conditions
Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody
No

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