Cyclin D2 Rabbit Polyclonal Antibody

• Description:

  The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with CDK4 or CDK6 and functions as a regulatory subunit of the complex, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with and be involved in the phosphorylation of tumor suppressor protein Rb. Knockout studies of the homologous gene in mouse suggest the essential roles of this gene in ovarian granulosa and germ cell proliferation. High level expression of this gene was observed in ovarian and testicular tumors. Mutations in this gene are associated with megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 3 (MPPH3).

• Product Name Alternative:

  CCND 2 antibody ccnd2 antibody CCND2_HUMAN antibody CyclinD2 antibody G1/S specific cyclin D2 antibody G1/S-specific cyclin-D2 antibody KIAK0002 antibody MGC102758 antibody MPPH3 antibody

• Abbreviation:

  CCND2

• Swiss Prot:

  P30279 Human, P30280 Mouse, Q04827 Rat

• Cellular Locus:

  Nucleus, Cytoplasm, Membrane.

• Host:

  Rabbit

• Species Reactivity:

  Human, Mouse, Rat

• Immunogen:

  Synthetic peptide within human Cyclin D2 aa 30-79.

• Isotype:

  IgG

• Conjugation:

  Non-conjugated

• Type:

  Rabbit polyclonal Antibody

• Applications:

  WB

• Positive Control:

  Mouse spleen tissue lysate, Hela cell lysate, rat spleen tissue lysates.

• Concentration:

  1 mg/mL

• Dilution:

  WB: 1:500-1:1,000

• Purity:

  Immunogen affinity purified.

• Form:

  Liquid

• Buffer:

  1*TBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.

• Molecular Weight:

  Predicted band size: 33 kDa

• Storage Conditions:

  Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.

• Recombinant Antibody:

  No

• CAS Number:

  9007-83-4