Cyclin A1 Rabbit Polyclonal Antibody

• Description:

  The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell division cycle. Cyclins function as activating subunits of enzymatic complex together with cyclin-dependent kinases (CDKs). Different cyclins exhibit distinct expression and degradation patterns that contribute to the temporal coordination of cell cycle events. Cyclin A1 was shown to be expressed in testis and brain, as well as in several leukemic cell lines, and is thought to primarily function in the control of meiosis. This cyclin binds both Cdk1 and Cdk2 kinases, which give two distinct kinase activities, one appearing in S phase, the other in G2, and thus regulate separate functions in cell cycle. This cyclin was found to bind to important cell cycle regulators, such as Rb family proteins, transcription factor E2F1, and the Kip/Cip family of CDK-inhibitor proteins.

• Product Name Alternative:

  CCN A1 antibody CCNA 1 antibody Ccna1 antibody CCNA1_HUMAN antibody Cyclin-A1 antibody CyclinA1 antibody G2/mitotic specific cyclin A1 antibody MGC132235 antibody MGC159139 antibody

• Abbreviation:

  Cyclin-A1 CCN1

• Swiss Prot:

  P78396 Human, Q6AY13 Rat

• Cellular Locus:

  Nucleus.

• Host:

  Rabbit

• Species Reactivity:

  Human, Rat

• Immunogen:

  Recombinant protein within human Cyclin A1 aa 80-300 / 465.

• Isotype:

  IgG

• Conjugation:

  Non-conjugated

• Type:

  Rabbit polyclonal Antibody

• Applications:

  WB, FC

• Positive Control:

  Rat testis tissue lysates, SH-SY5Y.

• Concentration:

  1 mg/mL

• Dilution:

  WB: 1:500-1:2,000 ;FC: 1:100-1:500

• Purity:

  Immunogen affinity purified.

• Form:

  Liquid

• Buffer:

  1*TBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.

• Molecular Weight:

  52/47 kDa

• Storage Conditions:

  Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.

• Recombinant Antibody:

  No

• CAS Number:

  9007-83-4