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GRK3 Rabbit Polyclonal Antibody

CAT: 0992-HA500317Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0992-HA500317Size:100 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
G protein-coupled receptor kinases phosphorylate activated G protein-coupled receptors, which promotes the binding of an arrestin protein to the receptor. Arrestin binding to phosphorylated, active receptor prevents receptor stimulation of heterotrimeric G protein transducer proteins, blocking their cellular signaling and resulting in receptor desensitization. Arrestin binding also directs receptors to specific cellular internalization pathways, removing the receptors from the cell surface and also preventing additional activation. Arrestin binding to phosphorylated, active receptor also enables receptor signaling through arrestin partner proteins. Thus the GRK/arrestin system serves as a complex signaling switch for G protein-coupled receptors.
CAS Number
9007-83-4
Product Name Alternative
ADRBK2 antibody Adrenergic, beta, receptor kinase 2 antibody ARBK2_HUMAN antibody BARK2 antibody Beta adrenergic receptor kinase 2 antibody Beta ARK 2 antibody Beta-adrenergic receptor kinase 2 antibody Beta-ARK-2 antibody EC 2.7.11.15 antibody G protein coupled receptor kinase 3 antibody G-protein-coupled receptor kinase 3 antibody GRK3 antibody
Abbreviation
Beta-adrenergic receptor kinase 2 Beta-ARK-2 G-protein-coupled receptor kinase 3
Swiss Prot
P35626 Human, P26819 Rat
Cellular Locus
cytosol, plasma membrane.
Host
Rabbit
Species Reactivity
Human, Rat
Immunogen
Recombinant protein within human GRK3 aa 450-688 / 688.
Isotype
IgG
Conjugation
Non-conjugated
Type
Rabbit polyclonal Antibody
Applications
WB, IF-Cell, FC
Positive Control
Jurkat cell lysate, SHSY5Y cell lysate, HL-60 cell lysate, rat stomachl tissue lysate, MG-63, SiHa, SH-SY5Y.
Concentration
1 mg/mL
Dilution
WB: 1:1,000;IF-Cell: 1:50-1:200;FC: 1:500-1,000
Purity
Immunogen affinity purified.
Form
Liquid
Buffer
1*TBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight
Predicted band size: 80 kDa
Storage Conditions
Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody
No

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