MyT1L Rabbit Polyclonal Antibody

MyT1L Rabbit Polyclonal Antibody

• Description: Transcription factor that plays a key role in neuronal differentiation by specifically repressing expression of non-neuronal genes during neuron differentiation. In contrast to other transcription repressors that inhibit specific lineages, mediates repression of multiple differentiation programs. Also represses expression of negative regulators of neurogenesis, such as members of the Notch signaling pathway, including HES1. The combination of three transcription factors, ASCL1, POU3F2/BRN2 and MYT1L, is sufficient to reprogram fibroblasts and other somatic cells into induced neuronal (iN) cells in vitro. Directly binds the 5'-AAGTT-3' core motif present on the promoter of target genes and represses transcription by recruiting a multiprotein complex containing SIN3B. The 5'-AAGTT-3' core motif is absent from the promoter of neural genes.
• Product Name Alternative: Myelin transcription factor 1-like protein antibody MyT1-L antibody MyT1L antibody MYT1L_HUMAN antibody neural zinc finger transcription factor 1 antibody
• Abbreviation: Myelin transcription factor 1-like protein MyT1-L MyT1L
• CAS Number: 9007-83-4
• Swiss Prot: Q9UL68 Human, P97500 Mouse
• Cellular Locus: Chromosome, Nucleus.
• Host: Rabbit
• Species Reactivity: Human, Mouse
• Immunogen: Recombinant protein within human MyT1L aa 200-400 / 1186.
• Isotype: IgG
• Conjugation: Non-conjugated
• Type: Rabbit polyclonal Antibody
• Applications: WB, IHC-P, FC
• Positive Control: SHSY5Y cell lysates, mouse cerebellum tissue, mouse brain tissue, SH-SY5Y.
• Concentration: 1 mg/mL
• Dilution: WB: 1:500-1:1000;IHC-P: 1:100-1:500;FC: 1:100-1:500
• Purity: Immunogen affinity purified.
• Form: Liquid
• Buffer: 1*TBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
• Molecular Weight: 133 kDa
• Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
• Recombinant Antibody: No