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PRR5 Rabbit Polyclonal Antibody

CAT: 0992-HA500295Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0992-HA500295Size:100 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals. mTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be nutrient-insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 'Ser-473' phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of SGK1 at 'Ser-422'. mTORC2 also modulates the phosphorylation of PRKCA on 'Ser-657'. PRR5 plays an important role in regulation of PDGFRB expression and in modulation of platelet-derived growth factor signaling. May act as a tumor suppressor in breast cancer.
CAS Number
9007-83-4
Product Name Alternative
Arhgap8 antibody AU043908 antibody C030017C09Rik antibody C78947 antibody FLJ20185 antibody FLJ20185k antibody MGC109513 antibody MGC32512 antibody PP610 antibody Proline rich 5 (renal) antibody Proline-rich protein 5 antibody Protein observed with Rictor-1 antibody Protor-1 antibody PROTOR1 antibody PRR5 antibody PRR5_HUMAN antibody PTOR1 antibody Rho GTPase activating protein 8 antibody RP1-181C9.3 antibody
Abbreviation
Proline-rich protein 5 Protein observed with Rictor-1 Protor-1 PP610 PROTOR1 RR5
Swiss Prot
P85299 Human, Q812A5 Mouse, Q5FVG6 Rat
Cellular Locus
Cytosol.
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Immunogen
Recombinant protein within human Protor-1 aa 200-388 / 388.
Isotype
IgG
Conjugation
Non-conjugated
Type
Rabbit polyclonal Antibody
Applications
WB
Positive Control
MCF-7 cell lysate, mouse liver tissue lysate, rat liver tissue lysate.
Concentration
1 mg/mL
Dilution
WB: 1:500-1:1000
Purity
Immunogen affinity purified.
Form
Liquid
Buffer
1*TBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight
42/31/32/45 kDa
Storage Conditions
Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody
No

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