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TEAD1 Rabbit Polyclonal Antibody

CAT: 0992-HA500277Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0992-HA500277Size:100 µL
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Description
Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds specifically and cooperatively to the SPH and GT-IIC 'enhansons' (5'-GTGGAATGT-3') and activates transcription in vivo in a cell-specific manner. The activation function appears to be mediated by a limiting cell-specific transcriptional intermediary factor (TIF). Involved in cardiac development. Binds to the M-CAT motif.
CAS Number
9007-83-4
Product Name Alternative
AA antibody Atrophia areata peripapillary chorioretinal degeneration antibody NTEF 1 antibody NTEF-1 antibody NTEF1 antibody Protein GT IIC antibody Protein GT-IIC antibody REF 1 antibody REF1 antibody SV40 transcriptional enhancer factor antibody TCF 13 antibody TCF-13 antibody TCF13 antibody TEA domain family member antibody TEA domain family member 1 (SV40 transcriptional enhancer factor) antibody TEA domain family member 1 antibody TEAD 1 antibody TEAD 1 protein antibody TEAD-1 antibody TEAD1 antibody TEAD1 protein antibody TEAD1_HUMAN antibody TEF 1 antibody TEF1 antibody Transcription factor 13 (SV40 transcriptional enhancer factor) antibody Transcription factor 13 antibody Transcriptional enhancer factor 1 antibody Transcriptional enhancer factor TEF-1 antibody Transcriptional enhancer factor TEF1 antibody
Abbreviation
TEAD1
Swiss Prot
P28347 Human, P30051 Mouse,
Cellular Locus
Nucleus.
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Immunogen
Recombinant protein within human TEAD1 aa 1-150 / 426.
Isotype
IgG
Conjugation
Non-conjugated
Type
Rabbit polyclonal Antibody
Applications
WB, IHC-P, FC
Positive Control
Mouse liver tissue lysate, mouse skeletal muscle tissue lysate, rat skeletal muscle tissue, human fetal skeletal muscle tissue, Hela.
Concentration
1 mg/mL
Dilution
WB: 1:500 ;IHC-P: 1:400 ;FC: 1:500-1:1,000
Purity
Immunogen affinity purified.
Form
Liquid
Buffer
1*TBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight
Predicted band size: 48 kDa
Storage Conditions
Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody
No

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