ClC2 Rabbit Polyclonal Antibody

• Description :

  This gene encodes a voltage-gated chloride channel. The encoded protein is a transmembrane protein that maintains chloride ion homeostasis in various cells. Defects in this gene may be a cause of certain epilepsies. Four transcript variants encoding different isoforms have been found for this gene. Voltage-gated chloride channel. Chloride channels have several functions including the regulation of cell volume, membrane potential stabilization, signal transduction and transepithelial transport. Involved in the regulation of aldosterone production. The opening of CLCN2 channels at hyperpolarized membrane potentials in the glomerulosa causes cell membrane depolarization, activation of voltage-gated Ca2+ channels and increased expression of aldosterone synthase, the rate-limiting enzyme for aldosterone biosynthesis.

• Product Name Alternative :

  Chloride Channel 2 antibody Chloride channel protein 2 antibody Chloride channel, voltage sensitive 2 antibody CIC 2 antibody CIC2 antibody ClC-2 antibody CLC2 antibody Clcn2 antibody CLCN2_HUMAN antibody ECA2 antibody ECA3 antibody EG13 antibody EGI11 antibody EGMA antibody EJM6 antibody EJM8 antibody PKA-activated chloride channel antibody

• Abbreviation :

  CLCN2

• Swiss Prot :

  P51788 Human, P35525 Rat

• Cellular Locus :

  Cell membrane.

• Host :

  Rabbit

• Species Reactivity :

  Human, Rat

• Immunogen :

  Recombinant protein within human ClC2 aa 631-830.

• Isotype :

  IgG

• Conjugation :

  Non-conjugated

• Type :

  Rabbit polyclonal Antibody

• Applications :

  WB, IF-Cell, IHC-P, FC

• Positive Control :

  HepG2 cell lysate, 293 cell lysate, human kidney tissue, human stomach tissue, rat colon tissue, SiHa, Hela.

• Concentration :

  1 mg/mL

• Dilution :

  WB: 1:500;IF-Cell: 1:200;IHC-P: 1:200;FC: 1:500-1:1,000

• Purity :

  Immunogen affinity purified.

• Form :

  Liquid

• Buffer :

  1*TBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.

• Molecular Weight :

  Predicted band size: 99 kDa

• Storage Conditions :

  Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.

• Recombinant Antibody :

  No

• CAS Number :

  9007-83-4