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ClC2 Rabbit Polyclonal Antibody

CAT: 0992-HA500243Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0992-HA500243Size:100 µL
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Description
This gene encodes a voltage-gated chloride channel. The encoded protein is a transmembrane protein that maintains chloride ion homeostasis in various cells. Defects in this gene may be a cause of certain epilepsies. Four transcript variants encoding different isoforms have been found for this gene. Voltage-gated chloride channel. Chloride channels have several functions including the regulation of cell volume, membrane potential stabilization, signal transduction and transepithelial transport. Involved in the regulation of aldosterone production. The opening of CLCN2 channels at hyperpolarized membrane potentials in the glomerulosa causes cell membrane depolarization, activation of voltage-gated Ca2+ channels and increased expression of aldosterone synthase, the rate-limiting enzyme for aldosterone biosynthesis.
CAS Number
9007-83-4
Product Name Alternative
Chloride Channel 2 antibody Chloride channel protein 2 antibody Chloride channel, voltage sensitive 2 antibody CIC 2 antibody CIC2 antibody ClC-2 antibody CLC2 antibody Clcn2 antibody CLCN2_HUMAN antibody ECA2 antibody ECA3 antibody EG13 antibody EGI11 antibody EGMA antibody EJM6 antibody EJM8 antibody PKA-activated chloride channel antibody
Abbreviation
CLCN2
Swiss Prot
P51788 Human, P35525 Rat
Cellular Locus
Cell membrane.
Host
Rabbit
Species Reactivity
Human, Rat
Immunogen
Recombinant protein within human ClC2 aa 631-830.
Isotype
IgG
Conjugation
Non-conjugated
Type
Rabbit polyclonal Antibody
Applications
WB, IF-Cell, IHC-P, FC
Positive Control
HepG2 cell lysate, 293 cell lysate, human kidney tissue, human stomach tissue, rat colon tissue, SiHa, Hela.
Concentration
1 mg/mL
Dilution
WB: 1:500;IF-Cell: 1:200;IHC-P: 1:200;FC: 1:500-1:1,000
Purity
Immunogen affinity purified.
Form
Liquid
Buffer
1*TBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight
Predicted band size: 99 kDa
Storage Conditions
Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody
No