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SF3A1 Rabbit Polyclonal Antibody

CAT: 0992-HA500235Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0992-HA500235Size:100 µL
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Description
This gene encodes subunit 1 of the splicing factor 3a protein complex. The splicing factor 3a heterotrimer includes subunits 1, 2 and 3 and is necessary for the in vitro conversion of 15S U2 snRNP into an active 17S particle that performs pre-mRNA splicing. Subunit 1 belongs to the SURP protein family; named for the SURP (also called SWAP or Suppressor-of-White-APricot) motifs that are thought to mediate RNA binding. Subunit 1 has tandemly repeated SURP motifs in its amino-terminal half while its carboxy-terminal half contains a proline-rich region and a ubiquitin-like domain. Binding studies with truncated subunit 1 derivatives demonstrated that the two SURP motifs are necessary for binding to subunit 3 while contacts with subunit 2 may occur through sequences carboxy-terminal to the SURP motifs. Alternative splicing results in multiple transcript variants encoding different isoforms.
CAS Number
9007-83-4
Product Name Alternative
Pre mRNA processing 21 antibody Pre mRNA splicing factor SF3a antibody PRP21 antibody PRPF21 antibody SAP 114 antibody SAP114 antibody sf3a1 antibody SF3A1_HUMAN antibody SF3a120 antibody Spliceosome associated protein 114 antibody Spliceosome-associated protein 114 antibody Splicing factor 3 subunit 1 antibody Splicing factor 3a subunit 1 120kDa antibody Splicing factor 3A subunit 1 antibody
Abbreviation
SF3A1
Swiss Prot
Q15459 Human, Q8K4Z5 Mouse,
Cellular Locus
Nucleus, Nucleus speckle.
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Immunogen
Synthetic peptide within human SF3A1 aa 50-100 / 793.
Isotype
IgG
Conjugation
Non-conjugated
Type
Rabbit polyclonal Antibody
Applications
WB, IHC-P
Positive Control
Jurkat cell lysate, HeLa cell lysate, A549 cell lysate, K-562 cell lysate, mouse brain tissue lysate, rat lung tissue lysate, human colon carcinoma tissue, mouse brain tissue, mouse lung tissue.
Concentration
1 mg/mL
Dilution
WB: 1:500-1:1,000 ;IHC-P: 1:50-1:200
Purity
Immunogen affinity purified.
Form
Liquid
Buffer
1*TBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight
Predicted band size: 89 kDa
Storage Conditions
Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody
No

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