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PRDC Rabbit Polyclonal Antibody

CAT: 0992-HA500225Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0992-HA500225Size:100 µL
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Description
PRDC (protein related to DAN and Cerberus) is a secreted cysteine knot-containing BMP antagonist belonging to the Cerberus/DAN (CAN) family. Mammalian CAN family members, including Gremlin, Dan, Cerberus, COCO, SOST, and USAG-1, have the conserved 6 cysteine residues that form a cysteine knot, and two additional cysteine residues located in the loops of the cysteine knot, which form an additional intrasubunit disulfide bond. PRDC acts as a specific BMP antagonist, binding to and blocking signaling induced by BMP-2 or -4, but not Activin or TGF-beta. Thus, PRDC expression in the ovary could be involved in follicular development by antagonizing the inhibitory effects of BMPs on FSH stimulation of progesterone
CAS Number
9007-83-4
Product Name Alternative
BMP antagonist 2 antibody CKTSF1B2 antibody Cysteine knot superfamily 1 antibody Cysteine knot superfamily 1 BMP antagonist 2 antibody DAN domain family member 3 antibody DAND 3 antibody DAND3 antibody GREM 2 antibody Grem2 antibody GREM2_HUMAN antibody Gremlin 2 antibody Gremlin 2 cysteine knot superfamily homolog antibody Gremlin-2 antibody Gremlin2 antibody PRDC antibody Protein related to DAN and cerberus antibody
Abbreviation
GREM2
Swiss Prot
Q9H772 Human
Cellular Locus
Secreted.
Host
Rabbit
Species Reactivity
Human
Immunogen
Synthetic peptide within human PRDC aa 50-100.
Isotype
IgG
Conjugation
Non-conjugated
Type
Rabbit polyclonal Antibody
Applications
WB, FC
Positive Control
CAL62 cell lysates, SH-SY5Y.
Concentration
1 mg/mL
Dilution
WB: 1:500-1:1,000 ;FC: 1:200-1:500
Purity
Immunogen affinity purified.
Form
Liquid
Buffer
1*TBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight
Predicted band size: 19 kDa.
Storage Conditions
Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody
No

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