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SREBP1 Rabbit Polyclonal Antibody

CAT: 0992-HA500210Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0992-HA500210Size:100 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
This gene encodes a basic helix-loop-helix-leucine zipper (bHLH-Zip) transcription factor that binds to the sterol regulatory element-1 (SRE1), which is a motif that is found in the promoter of the low density lipoprotein receptor gene and other genes involved in sterol biosynthesis. The encoded protein is synthesized as a precursor that is initially attached to the nuclear membrane and endoplasmic reticulum. Following cleavage, the mature protein translocates to the nucleus and activates transcription. This cleaveage is inhibited by sterols. This gene is located within the Smith-Magenis syndrome region on chromosome 17. Alternative promoter usage and splicing result in multiple transcript variants, including SREBP-1a and SREBP-1c, which correspond to RefSeq transcript variants 2 and 3, respectively.
CAS Number
9007-83-4
Product Name Alternative
ADD 1 antibody bHLHd1 antibody Class D basic helix-loop-helix protein 1 antibody D630008H06 antibody Processed sterol regulatory element-binding protein 1 antibody SRBP1_HUMAN antibody SREBF 1 antibody SREBF1 antibody SREBP 1 antibody SREBP 1c antibody SREBP-1 antibody SREBP1 antibody Sterol regulatory element binding protein 1 antibody Sterol Regulatory Element Binding Transcription Factor 1 / Protein 1 antibody Sterol regulatory element binding transcription factor 1 antibody Sterol regulatory element-binding transcription factor 1 antibody
Abbreviation
SREBF1
Swiss Prot
P36956 Human, Q9WTN3 Mouse
Cellular Locus
Endoplasmic reticulum membrane, Golgi apparatus membrane, COPII-coated vesicle membrane; Nucleus.
Host
Rabbit
Species Reactivity
Human, Mouse
Immunogen
Synthetic peptide within N-terminal human SREBP1 from aa25-aa55.
Isotype
IgG
Conjugation
Non-conjugated
Type
Rabbit polyclonal Antibody
Applications
WB, IF-Cell, IHC-P
Positive Control
HepG2 cell lysate, mouse heart tissue lysate, mouse liver tissue lysate, 293 cell lysate, Jurkat cell lysate, A549 cell lysate, Hela, human lung tissue, human placenta tissue.
Concentration
1 mg/mL
Dilution
WB: 1:500-1:2,000 ;IF-Cell: 1:50-1:100 ;IHC-P: 1:100-1:500
Purity
Immunogen affinity purified.
Form
Liquid
Buffer
1*TBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight
122 kDa
Storage Conditions
Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody
No

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