Claudin18 Rabbit Polyclonal Antibody

Claudin18 Rabbit Polyclonal Antibody

• Description: Claudin-18 is a tight junction protein expressed as lung-and stomach-specific isoforms which are generated by alternative splicing of the claudin-18 gene. The lung-specific form is a downstream target gene regulated by the T/EBP/NKX2.1 transcription factor. A splice variant lacking the C-terminal cytoplasmic domain also exists in mouse, but has not been confirmed in human. Human claudin-18 demonstrates 88% amino acid sequence identity to the mouse protein. Immunohistochemical studies have demonstrated complete membrane localization of claudin-18 in lung and stomach epithelial cells, while electron microscopy has shown that it is concentrated in the cell-cell borders of these cells. These features suggest a potentially important role for claudin-18 in the structure and function of tight junctions in the lung and stomach. Claudin-18 expression has also been reported in the inner ear.
• Product Name Alternative: Claudin 18 antibody Claudin-18 antibody CLD18_HUMAN antibody CLDN18 antibody SFTA5 antibody SFTPJ antibody
• Abbreviation: CLDN18
• CAS Number: 9007-83-4
• Swiss Prot: P56856 Human
• Cellular Locus: Cell membrane, tight junction.
• Host: Rabbit
• Species Reactivity: Human
• Immunogen: Synthetic peptide within C-terminal human Claudin18.
• Isotype: IgG
• Conjugation: Non-conjugated
• Type: Rabbit polyclonal Antibody
• Applications: WB, IHC-P
• Positive Control: 293T cell lysates, human gastric carcinoma tissue.
• Concentration: 1 mg/mL
• Dilution: WB: 1:500-1:1,000 ;IHC-P:1:100-1:500
• Purity: Immunogen affinity purified.
• Form: Liquid
• Buffer: 1*TBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
• Molecular Weight: 28 kDa
• Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
• Recombinant Antibody: No