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SYK Rabbit Polyclonal Antibody

CAT: 0992-HA500080Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0992-HA500080Size:100 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Non-receptor tyrosine kinase which mediates signal transduction downstream of a variety of transmembrane receptors including classical immunoreceptors like the B-cell receptor (BCR). Regulates several biological processes including innate and adaptive immunity, cell adhesion, osteoclast maturation, platelet activation and vascular development. Assembles into signaling complexes with activated receptors at the plasma membrane via interaction between its SH2 domains and the receptor tyrosine-phosphorylated ITAM domains. More rarely signal transduction via SYK could be ITAM-independent. Direct downstream effectors phosphorylated by SYK include VAV1, PLCG1, PI-3-kinase, LCP2 and BLNK. Activated upon BCR engagement, it phosphorylates and activates BLNK an adapter linking the activated BCR to downstream signaling adapters and effectors. It also phosphorylates and activates PLCG1 and the PKC signaling pathway. It also phosphorylates BTK and regulates its activity in B-cell antigen receptor (BCR)-coupled signaling. In addition to its function downstream of BCR plays also a role in T-cell receptor signaling.
CAS Number
9007-83-4
Product Name Alternative
EC 2.7.10.2 antibody kinase Syk antibody KSYK antibody KSYK_HUMAN antibody p72-Syk antibody p72syk antibody Spleen tyrosine kinase antibody Syk antibody Tyrosine protein kinase SYK antibody Tyrosine-protein kinase SYK antibody
Abbreviation
Tyrosine-protein kinase SYK Spleen tyrosine kinase p72-Syk
Swiss Prot
P43405 Human, Q64725 Rat
Cellular Locus
Cell membrane, Cytoplasm, Membrane.
Host
Rabbit
Species Reactivity
Human, Rat
Immunogen
Recombinant protein within human SYK aa 1-200.
Isotype
IgG
Conjugation
Non-conjugated
Type
Rabbit polyclonal Antibody
Applications
WB, IF-Cell, IHC-P
Positive Control
Raji cell lysate, Daudi cell lysate, MCF-7, PANC-1, rat kidney tissue, rat heart tissue.
Concentration
1 mg/mL
Dilution
WB: 1:500-1:1,000;IF-Cell: 1:50-1:200
Purity
Immunogen affinity purified.
Form
Liquid
Buffer
1*TBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight
72 kDa
Storage Conditions
Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody
No

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