CHMP2A Rabbit Polyclonal Antibody

• Description :

  Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis. Together with SPAST, the ESCRT-III complex promotes nuclear envelope sealing and mitotic spindle disassembly during late anaphase. ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4.

• Product Name Alternative :

  BC 2 antibody BC2 antibody Charged multivesicular body protein 2a antibody CHM2A_HUMAN antibody CHMP2 antibody CHMP2a antibody Chromatin modifying protein 2a antibody Chromatin-modifying protein 2a antibody hVps2 1 antibody hVps2-1 antibody putative breast adenocarcinoma marker antibody Putative breast adenocarcinoma marker BC-2 antibody Putative breast adenocarcinoma marker BC2 antibody Vacuolar protein sorting associated protein 2 1 antibody Vacuolar protein sorting-associated protein 2-1 antibody Vps2 1 antibody VPS2 antibody Vps2-1 antibody VPS2A antibody

• Abbreviation :

  CHMP2A

• Swiss Prot :

  O43633 Human, Q9DB34 Mouse, B2RZB5 Rat

• Cellular Locus :

  Late endosome membrane.

• Host :

  Rabbit

• Species Reactivity :

  Human, Mouse, Rat

• Immunogen :

  Synthetic peptide within N-terminal human CHMP2A.

• Isotype :

  IgG

• Conjugation :

  Non-conjugated

• Type :

  Rabbit polyclonal Antibody

• Applications :

  WB, IF-Cell, IHC-P

• Positive Control :

  SW480 cell lysate, A431 cell lysate, HepG2 cell lysate, rat bladder tissue.

• Concentration :

  1 mg/mL

• Dilution :

  WB: 1:500-1:2,000;IF-Cell: 1:50-1:100;IHC-P: 1:200-1:1,000

• Purity :

  Immunogen affinity purified.

• Form :

  Liquid

• Buffer :

  1*TBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.

• Molecular Weight :

  Predicted band size:25 kDa.

• Storage Conditions :

  Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.

• Recombinant Antibody :

  No

• CAS Number :

  9007-83-4