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RhoGDI Rabbit Polyclonal Antibody

CAT: 0992-HA500067Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0992-HA500067Size:100 µL
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Description
Controls Rho proteins homeostasis. Regulates the GDP/GTP exchange reaction of the Rho proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them. Retains Rho proteins such as CDC42, RAC1 and RHOA in an inactive cytosolic pool, regulating their stability and protecting them from degradation. Actively involved in the recycling and distribution of activated Rho GTPases in the cell, mediates extraction from membranes of both inactive and activated molecules due its exceptionally high affinity for prenylated forms. Through the modulation of Rho proteins, may play a role in cell motility regulation. In glioma cells, inhibits cell migration and invasion by mediating the signals of SEMA5A and PLXNB3 that lead to inactivation of RAC1. Activity of this protein is important in a variety of cellular processes, and expression of this gene may be altered in tumors. Mutations in this gene have been found in individuals with nephrotic syndrome, type 8. Alternate splicing results in multiple transcript variants.
CAS Number
9007-83-4
Product Name Alternative
ARHGDIA antibody fa96g11 antibody GDIA 1 antibody GDIA1 antibody GDIR1_HUMAN antibody MGC117248 antibody NPHS8 antibody Rho GDI 1 antibody Rho GDI alpha antibody Rho GDI antibody Rho GDP dissociation inhibitor (GDI) alpha antibody Rho GDP dissociation inhibitor 1 antibody Rho GDP dissociation inhibitor alpha antibody Rho GDP-dissociation inhibitor 1 antibody Rho-GDI alpha antibody RhoGDI 1 antibody RhoGDI alpha antibody RHOGDI antibody RhoGDI1 antibody wu:fa96g11 antibody zgc:55554 antibody zgc:77681 antibody
Abbreviation
ARHGDIA
Swiss Prot
P52565 Human, Q99PT1 Mouse, Q5XI73 Rat
Cellular Locus
Cytoplasm.
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Immunogen
Recombinant protein within human RhoGDI aa 50-204.
Isotype
IgG
Conjugation
Non-conjugated
Type
Rabbit polyclonal Antibody
Applications
WB, IF-Cell, IHC-P
Positive Control
HepG2 cell lysate, SH-SY5Y cell lysate, rat lung tissue lysate, MG-63, SH-SY5Y, rat testis tissue, human lung tissue, human thyroid tissue, mouse thyroid tissue.
Concentration
1 mg/mL
Dilution
WB: 1:500-1:1,000 ;IF-Cell: 1:50-1:100 ;IHC-P: 1:50-1:200
Purity
Protein A affinity purified.
Form
Liquid
Buffer
1*TBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight
Predicted band size: 23 kDa
Storage Conditions
Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody
No

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