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Smg1 Rabbit Polyclonal Antibody

CAT: 0992-HA500054Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0992-HA500054Size:100 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Serine/threonine protein kinase involved in both mRNA surveillance and genotoxic stress response pathways. Recognizes the substrate consensus sequence [ST]-Q. Plays a central role in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons by phosphorylating UPF1/RENT1. Recruited by release factors to stalled ribosomes together with SMG8 and SMG9 (forming the SMG1C protein kinase complex), and UPF1 to form the transient SURF (SMG1-UPF1-eRF1-eRF3) complex. In EJC-dependent NMD, the SURF complex associates with the exon junction complex (EJC) through UPF2 and allows the formation of an UPF1-UPF2-UPF3 surveillance complex which is believed to activate NMD. Also acts as a genotoxic stress-activated protein kinase that displays some functional overlap with ATM. Can phosphorylate p53/TP53 and is required for optimal p53/TP53 activation after cellular exposure to genotoxic stress. Its depletion leads to spontaneous DNA damage and increased sensitivity to ionizing radiation (IR). May activate PRKCI but not PRKCZ.
CAS Number
9007-83-4
Product Name Alternative
61E3.4 antibody ATX antibody hSMG-1 antibody hSMG1 antibody KIAA0421 antibody Lambda interacting protein antibody Lambda-interacting protein antibody Lambda/iota protein kinase C interacting protein antibody Lambda/iota protein kinase C-interacting protein antibody LIP antibody Phosphatidylinositol 3 kinase related kinase antibody Phosphatidylinositol 3 kinase related protein kinase antibody PI 3 kinase related kinase SMG 1 antibody Serine/threonine protein kinase SMG1 antibody Serine/threonine-protein kinase SMG1 antibody SMG-1 antibody smg1 antibody SMG1_HUMAN antibody
Abbreviation
Serine/threonine-protein kinase SMG1 SMG-1 hSMG-1 61E3.4 Lambda/iota protein kinase C-interacting protein Lambda-interacting protein
Swiss Prot
Q96Q15 Human
Cellular Locus
Cytoplasm, Nucleus.
Host
Rabbit
Species Reactivity
Human
Immunogen
Recombinant protein within human Smg1 aa 3450-3661.
Isotype
IgG
Conjugation
Non-conjugated
Type
Rabbit polyclonal Antibody
Applications
WB, IHC-P
Positive Control
Hela cell lysates, human kidney tissue, human skeletal muscle tissue.
Concentration
1 mg/mL
Dilution
WB: 1:500-1:1,000 ;IHC-P: 1:100-1:500
Purity
Immunogen affinity purified.
Form
Liquid
Buffer
1*TBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight
Predicted band size: 410/395/340/269 kDa.
Storage Conditions
Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody
No

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