BRCA1 Rabbit Polyclonal Antibody

• Description:

  This gene encodes a nuclear phosphoprotein that plays a role in maintaining genomic stability, and it also acts as a tumor suppressor. The encoded protein combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC). This gene product associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complexes. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in this gene are responsible for approximately 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene. Many alternatively spliced transcript variants, some of which are disease-associated mutations, have been described for this gene, but the full-length natures of only some of these variants has been described. A related pseudogene, which is also located on chromosome 17, has been identified.

• Product Name Alternative:

  BRCA 1 antibody BRCA1 antibody BRCA1 DNA repair associated antibody BRCA1/BRCA2 containing complex subunit 1 antibody BRCA1/BRCA2-containing complex, subunit 1 antibody BRCA1_HUMAN antibody BRCAI antibody BRCC 1 antibody BRCC1 antibody Breast and ovarian cancer susceptibility protein 1 antibody Breast Cancer 1 antibody Breast Cancer 1 Early Onset antibody Breast cancer type 1 susceptibility protein antibody BROVCA1 antibody FANCS antibody IRIS antibody PNCA4 antibody PPP1R53 antibody Protein phosphatase 1 regulatory subunit 53 antibody PSCP antibody RING finger protein 53 antibody RNF53 antibody

• Abbreviation:

  BRCA1

• Swiss Prot:

  P38398 Human, P48754 Mouse, O54952 Rat

• Cellular Locus:

  Nucleus, Chromosome, Cytoplasm.

• Host:

  Rabbit

• Species Reactivity:

  Human, Mouse, Rat

• Immunogen:

  Recombinant protein within human BRCA1 aa 1-200.

• Isotype:

  IgG

• Conjugation:

  Non-conjugated

• Type:

  Rabbit polyclonal Antibody

• Applications:

  WB, IHC-P

• Positive Control:

  Daudi cell lysate, mouse testis tissue.

• Concentration:

  1 mg/mL

• Dilution:

  WB: 1:500-1:2,000 ;IHC-P: 1:200-1:1,000

• Purity:

  Immunogen affinity purified.

• Form:

  Liquid

• Buffer:

  1*TBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.

• Molecular Weight:

  Predicted band size: 80 kDa-208 kDa.

• Storage Conditions:

  Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.

• Recombinant Antibody:

  No

• CAS Number:

  9007-83-4