MUM1 Recombinant Rabbit Monoclonal Antibody [JE52-60]

MUM1 Recombinant Rabbit Monoclonal Antibody [JE52-60]

• Description: Interferon regulatory factor 4 also known as MUM1 is a protein that in humans is encoded by the IRF4 gene, located at 6p25-p23. In melanocytic cells the IRF4 gene may be regulated by MITF. IRF4 is a transcription factor that has been implicated in acute leukemia. This gene is strongly associated with pigmentation: sensitivity of skin to sun exposure, freckles, blue eyes, and brown hair color. A variant has been implicated in greying of hair. The World Health Organization (2016) provisionally defined large B-cell lymphoma with IRF4 rearrangement as a rare indolent large B-cell lymphoma of children and adolescents. This indolent lymphoma mimics, and must be distinguished from, pediatric-type follicular lymphoma. The hallmark of large B-cell lymphoma with IRF4 rearrangement is the overexpression of the IRF4 gene by the disease's malignant cells. Transcriptional activator. Binds to the interferon-stimulated response element (ISRE) of the MHC class I promoter. Binds the immunoglobulin lambda light chain enhancer, together with PU.1. Probably plays a role in ISRE-targeted signal transduction mechanisms specific to lymphoid cells. Involved in CD8+ dendritic cell differentiation by forming a complex with the BATF-JUNB heterodimer in immune cells, leading to recognition of AICE sequence (5'-TGAnTCA/GAAA-3'), an immune-specific regulatory element, followed by cooperative binding of BATF and IRF4 and activation of genes.
• Product Name Alternative: Interferon regulatory factor 4 antibody IRF 4 antibody IRF-4 antibody Irf4 antibody IRF4_HUMAN antibody LSIRF antibody Lymphocyte specific interferon regulatory factor antibody Lymphocyte specific IRF antibody Lymphocyte-specific interferon regulatory factor antibody Multiple myeloma oncogene 1 antibody MUM 1 antibody MUM1 antibody NF EM5 antibody NF-EM5 antibody NFEM5 antibody PU.1 interaction partner antibody Sfpi1/PU.1 interaction partner antibody Transcriptional activator PIP antibody
• Abbreviation: IRF4
• CAS Number: 9000-83-3
• Swiss Prot: Q15306 Human
• Cellular Locus: Nucleus.
• Host: Rabbit
• Species Reactivity: Human
• Immunogen: Recombinant protein within Human MUM1 aa 1-111 / 451.
• Isotype: IgG
• Conjugation: Non-conjugated
• Type: Recombinant Rabbit monoclonal Antibody
• Applications: WB, IHC-P
• Positive Control: Ramos cell lysate, human hodgkin’s lymphoma tissue, human tonsil tissue, human colon tissue.
• Concentration: 1 mg/mL
• Dilution: WB:1:500-1:2,000 ;IHC-P:1:50-1:200
• Purity: Protein A affinity purified.
• Form: Liquid
• Buffer: 1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
• Molecular Weight: Predicted band size: 52 kDa
• Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
• Recombinant Antibody: Yes