CaMKII delta Recombinant Rabbit Monoclonal Antibody [JA30-07]

CaMKII delta Recombinant Rabbit Monoclonal Antibody [JA30-07]

• Description: Calcium/calmodulin-dependent protein kinase involved in the regulation of Ca2homeostatis and excitation-contraction coupling (ECC) in heart by targeting ion channels, transporters and accessory proteins involved in Ca2influx into the myocyte, Ca2release from the sarcoplasmic reticulum (SR), SR Ca2uptake and Naand Kchannel transport. Targets also transcription factors and signaling molecules to regulate heart function. In its activated form, is involved in the pathogenesis of dilated cardiomyopathy and heart failure. Regulates Ca2influx to myocytes by binding and phosphorylating the L-type Ca2channel subunit beta-2 CACNB2. In addition to Ca2channels, can target and regulate the cardiac sarcolemmal Nachannel Nav1.5/SCN5A and the K+ channel Kv4.3/KCND3, which contribute to arrhythmogenesis in heart failure. Phosphorylates phospholamban (PLN/PLB), an endogenous inhibitor of SERCA2A/ATP2A2, contributing to the enhancement of SR Ca2uptake that may be important in frequency-dependent acceleration of relaxation (FDAR) and maintenance of contractile function during acidosis.
• Product Name Alternative: Calcium / calmodulin dependent protein kinase 2 delta antibody Calcium / calmodulin dependent protein kinase II delta antibody calcium/calmodulin-dependent protein kinase (CaM kinase) II delta antibody calcium/calmodulin-dependent protein kinase type II delta chain antibody Calcium/calmodulin-dependent protein kinase type II subunit delta antibody CAM kinase 2 delta antibody CAM kinase II delta antibody CaM kinase II delta subunit antibody CaM kinase II subunit delta antibody CaM-kinase II delta chain antibody CAMK 2d antibody CaMK-II delta subunit antibody CaMK-II subunit delta antibody CAMK2D antibody CAMKD antibody CAMKI antibody KCC2D_HUMAN antibody RATCAMKI antibody
• Abbreviation: CaM kinase II subunit delta, CaMK-II subunit delta, CAMK2D, CAMKD
• CAS Number: 9000-83-3
• Swiss Prot: Q13557 Human, Q6PHZ2 Mouse, P15791 Rat
• Cellular Locus: Sarcolemma. Sarcoplasmic reticulum membrane.
• Host: Rabbit
• Species Reactivity: Human, Mouse, Rat, Zebrafish
• Immunogen: Synthetic peptide within Human CaMKII delta aa 22-71 / 499.
• Isotype: IgG
• Conjugation: Non-conjugated
• Type: Recombinant Rabbit monoclonal Antibody
• Applications: WB, IHC-P
• Positive Control: Human skeletal muscle tissue lysate, rat heart tissue lysate, zebrafish tissue, rat brain tissue, mouse skeletal muscle tissue, mouse heart tissue.
• Concentration: 1 mg/mL
• Dilution: WB: 1:1,000-1:2,000 ;IHC-P: 1:50-1:200
• Purity: Protein A affinity purified.
• Form: Liquid
• Buffer: 1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
• Molecular Weight: 56 kDa
• Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
• Recombinant Antibody: Yes