CaMKII alpha Recombinant Rabbit Monoclonal Antibody [JM11-07]

CaMKII alpha Recombinant Rabbit Monoclonal Antibody [JM11-07]

• Description: The Ca2+/calmodulin-dependent protein kinases (CaM kinases) comprise a structurally related subfamily of serine/threonine kinases which include CaMKI, CaMKII and CaMKIV. CaMKII is a ubiquitously expressed serine/threonine protein kinase that is activated by Ca2+and calmodulin (CaM) and has been implicated in regulation of the cell cycle and transcription. There are four CaMKII isozymes designated α, β, γ and δ, which may or may not be co-expressed in the same tissue type. CaMKIV is stimulated by Ca2+ and CaM but also requires phosphorylation by a CaMK for full activation. Stimulation of the T cell receptor CD3 signaling complex with an anti-CD3 monoclonal antibody leads to a 10-40 fold increase in CaMKIV activity. An additional kinase, CaMKK, functions to activate CaMKI through the specific phosphorylation of the regulatory Threonine residue at position 177.
• Product Name Alternative: Alpha CaMKII antibody Calcium calmodulin dependent protein kinase II antibody Calcium/calmodulin dependent protein kinase II alpha B subunit antibody Calcium/calmodulin dependent protein kinase type II alpha chain antibody Calcium/calmodulin-dependent protein kinase (CaM kinase) II alpha antibody Calcium/calmodulin-dependent protein kinase II alpha antibody Calcium/calmodulin-dependent protein kinase II-alpha antibody Calcium/calmodulin-dependent protein kinase type II subunit alpha antibody Calcium/calmodulin-dependent protein kinase type IIA antibody CaM kinase II alpha chain antibody CaM kinase II alpha subunit antibody CaM kinase II subunit alpha antibody CaMK II alpha subunit antibody CaMK-II subunit alpha antibody Camk2a antibody CAMKA antibody CaMKII antibody CaMKIINalpha antibody EC 2.7.11.17 antibody KCC2A_HUMAN antibody KIAA0968 antibody MGC123320 antibody MGC139375 antibody MGC155201 antibody mKIAA0968 antibody PK2CDD antibody PKCCD antibody R74975 antibody zgc:112538 antibody zgc:123320 antibody
• Abbreviation: CaM kinase II subunit alpha, CaMK-II subunit alpha
• CAS Number: 9000-83-3
• Swiss Prot: Q9UQM7 Human, P11798 Mouse, P11275 Rat
• Cellular Locus: Cell junction, Cell projection, Synapse.
• Host: Rabbit
• Species Reactivity: Human, Mouse, Rat
• Immunogen: Synthetic peptide within Human CaMKII alpha aa 37-71 / 478.
• Isotype: IgG
• Conjugation: Non-conjugated
• Type: Recombinant Rabbit monoclonal Antibody
• Applications: WB, IP, FC, IHC-P, IF-Tissue, IF-Cell, IHC-Fr
• Positive Control: Mouse brain tissue, rat brain tissue lysates, rat testis tissue, mouse cerebellum tissue, rat brain tissue, Neuro-2a.
• Concentration: 1 mg/mL
• Dilution: WB: 1:1,000-1:2,000 ;IHC-P: 1:50-1:200 ;FC: 1:50-1:100 ;IP: 1:10-1:50 ;IF-Tissue: 1:50 ;IF-Cell: 1:100 ;IHC-Fr: 1:200
• Purity: Protein A affinity purified.
• Form: Liquid
• Buffer: 1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
• Molecular Weight: Predicted band size: 54 kDa
• Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
• Recombinant Antibody: Yes