Galectin 3 Recombinant Rabbit Monoclonal Antibody [JF39-10]

Galectin 3 Recombinant Rabbit Monoclonal Antibody [JF39-10]

• Description: Galectins are a family of soluble b-galactoside-binding animal lectins that modulate cell-to-cell adhesion and cell-to-extracellular matrix (ECM) inter- actions and play a role in tumor progression, pre-mRNA splicing and apop-tosis. The galectin-3 protein, also known as Mac-2, hMac-2, GALBP, CBP35 or LGALS3, contains a single carbohydrate binding domain, which binds galactose-containing glycoconjugates. Galectin-3 is expressed in colonic and intestinal epithelium, inflammatory macrophages, papillary and follicular carcinomas, neoplastic astrocytes and some B and T lymphocytes. Upregulated expression of galectin-3 is involved in cancer progression and metastasis. Galectin-3 mediates the endocytosis of β1 Integrins in a lactose-dependent manner and is associated with thyroid malignancy and Crohn's disease. It may also be used as a marker for diagnosing cases involving Hurthle cell adenomas and carcinomas.
• Product Name Alternative: 35 kDa lectin antibody Carbohydrate binding protein 35 antibody Carbohydrate-binding protein 35 antibody CBP 35 antibody CBP35 antibody Gal-3 antibody GAL3 antibody Galactose-specific lectin 3 antibody Galactoside-binding protein antibody GALBP antibody Galectin 3 internal gene,included antibody Galectin-3 antibody Galectin 3 antibody Galectin3 antibody GALIG antibody GBP antibody IgE binding protein antibody IgE-binding protein antibody L 31 antibody L 34 antibody L-31 antibody L-34 galactoside-binding lectin antibody L31 antibody Laminin-binding protein antibody Lectin L-29 antibody Lectin, galactose binding, soluble 3 antibody LEG3_HUMAN antibody LGALS2 antibody LGALS3 antibody MAC 2 antigen antibody Mac-2 antibody Mac-2 antigen antibody MAC2 antibody Macrophage galactose-specific lectin antibody MGC105387 antibody
• Abbreviation: Gal-3, CBP 35, GALBP, LGALS3
• CAS Number: 9000-83-3
• Swiss Prot: P17931 Human, P16110 Mouse, P08699 Rat
• Cellular Locus: Nucleus, Secreted, Cytoplasm.
• Host: Rabbit
• Species Reactivity: Human, Mouse, Rat
• Immunogen: Synthetic peptide within Human Galectin 3 aa 1-49 / 250.
• Isotype: IgG
• Conjugation: Non-conjugated
• Type: Recombinant Rabbit monoclonal Antibody
• Applications: WB, IF-Cell, IF-Tissue, FC, IHC-P
• Positive Control: NIH/3T3 cell lysate, Hela cell lysate, THP-1 cell lysate, HeLa, human thyroid carcinoma tissue, human colon tissue, rat bladder tissue.
• Concentration: 1 mg/mL
• Dilution: WB: 1:500-1:2,000 ;IF-Cell: 1:50-1:200 ;IF-Tissue: 1:50-1:200 ;FC: 1:1,000 ;IHC-P: 1:200-1:1,000
• Purity: Protein A affinity purified.
• Form: Liquid
• Buffer: 1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
• Molecular Weight: Predicted band size: 26 kDa
• Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
• Recombinant Antibody: Yes