LYVE1 Recombinant Rabbit Monoclonal Antibody [JF0979]

LYVE1 Recombinant Rabbit Monoclonal Antibody [JF0979]

• Description: Lymphatic vessel endothelial hyaluronan receptor-1 (LYVE-1) is expressed on the cell surface as a protein that is reduced by glycosidase treatment. LYVE-1 is abundant in spleen, lymph node, heart, lung and fetal liver, and is less abundant in appendix, bone marrow, placenta, muscle and adult liver. Expression of LYVE-1 is largely restricted to endothelial cells lining lymphatic vessels and splenic sinusoidal endothelial cells. LYVE-1 binds to both soluble and immobilized hyaluronan (HA) with greater specificity than HCAM. Like HCAM, the LYVE-1 molecule binds both soluble and immobilized HA. However, unlike HCAM, the LYVE-1 molecule co-localizes with HA on the luminal face of the lymph vessel wall and is completely absent from blood vessels. Hence, LYVE-1 is the first lymph-specific HA receptor to be characterized and is a uniquely powerful marker for lymph vessels themselves. LYVE-1 is used as a marker to study tumor lymphangiogenesis, which is an important area of investigation.
• Product Name Alternative: Cell surface retention sequence-binding protein 1 antibody CRSBP 1 antibody CRSBP-1 antibody CRSBP1 antibody extracellular link domain containing 1 antibody extracellular link domain-containing 1 antibody Extracellular link domain-containing protein 1 antibody HAR antibody Hyaluronic acid receptor antibody Lymphatic endothelium specific hyaluronan receptor antibody lymphatic vessel endothelial hyaluronan receptor 1 antibody Lymphatic vessel endothelial hyaluronic acid receptor 1 antibody LYVE 1 antibody LYVE-1 antibody LYVE1 antibody LYVE1_HUMAN antibody XLKD1 antibody
• Abbreviation: LYVE-1, CRSBP-1, LYVE1
• CAS Number: 9000-83-3
• Swiss Prot: Q9Y5Y7 Human
• Cellular Locus: Membrane.
• Host: Rabbit
• Species Reactivity: Human
• Immunogen: Synthetic peptide within Human LYVE1 aa 36-72 / 322.
• Isotype: IgG
• Conjugation: Non-conjugated
• Type: Recombinant Rabbit monoclonal Antibody
• Applications: WB, FC
• Positive Control: MCF-7 cell lysate, SW480 cell lysate, A431 cell lysate, HUVEC cell lysate, A431, HUVEC, SW480.
• Concentration: 1 mg/mL
• Dilution: WB: 1:500-1:2,000 ;FC: 1:50-1:100
• Purity: Protein A affinity purified.
• Form: Liquid
• Buffer: 1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
• Molecular Weight: Predicted band size: 35 kDa
• Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
• Recombinant Antibody: Yes