Peroxiredoxin 1 Recombinant Rabbit Monoclonal Antibody [JF0945]

Peroxiredoxin 1 Recombinant Rabbit Monoclonal Antibody [JF0945]

• Description: The peroxiredoxin (PRX) family comprises six antioxidant proteins, PRX I, II, III, IV, V and VI, which protect cells from reactive oxygen species (ROS) by preventing the metal-catalyzed oxidation of enzymes. The PRX proteins primarily utilize thioredoxin as the electron donor for antioxidation, although they are fairly promiscuous with regard to the hydroperoxide substrate. In addition to protection from ROS, peroxiredoxins are also involved in cell proliferation, differentiation and gene expression. PRX I, II, IV and VI show diffuse cytoplasmic localization, while PRX III and V exhibit distinct mitochondrial localization. The human PRX I gene encodes a protein that is expressed in several tissues, including liver, kidney, testis, lung and nervous system. PRX II is expressed in testis, while PRX III shows expression in lung. PRX I, II and III are overexpressed in breast cancer and may be involved in its development or progression. Upregulated protein levels of PRX I and II in Alzheimer's disease (AD) and Down syndrome (DS) indicate the involvement of PRX I and II in their pathogenesis. The human PRX IV gene is abundantly expressed in many tissues.
• Product Name Alternative: Heme binding 23 kDa protein antibody MSP23 antibody Natural killer cell-enhancing factor A antibody NKEF A antibody NKEF-A antibody NKEFA antibody OSF3 antibody Osteoblast specific factor 3 antibody PAG antibody Paga antibody PAGB antibody Peroxiredoxin-1 antibody PRDX1 antibody PRDX1_HUMAN antibody Proliferation associated gene A antibody Proliferation-associated gene protein antibody PRX1 antibody PrxI antibody TDPX2 antibody Thioredoxin peroxidase 2 antibody Thioredoxin-dependent peroxide reductase 2 antibody
• Abbreviation: NKEF-A, PAG, PRDX1
• CAS Number: 9000-83-3
• Swiss Prot: Q06830 Human, P35700 Mouse
• Cellular Locus: Cytoplasm, Melanosome.
• Host: Rabbit
• Species Reactivity: Human, Mouse
• Immunogen: Synthetic peptide within N-terminal human Peroxiredoxin 1.
• Isotype: IgG
• Conjugation: Non-conjugated
• Type: Recombinant Rabbit monoclonal Antibody
• Applications: WB, IF-Tissue, IHC-P
• Positive Control: HeLa cell lysate, NIH/3T3 cell lysate, Mouse brain tissue lysate, human liver cancer tissue, mouse kidney tissue, human kidney tissue.
• Concentration: 1 mg/mL
• Dilution: WB: 1:1,000-1:5,000 ;IF-Tissue: 1:100-1:500 ;IHC-P: 1:200-1:1,000
• Purity: Protein A affinity purified.
• Form: Liquid
• Buffer: 1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
• Molecular Weight: Predicted band size: 22 kDa
• Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
• Recombinant Antibody: Yes