Cystatin C Recombinant Rabbit Monoclonal Antibody [JJ09-16]

Cystatin C Recombinant Rabbit Monoclonal Antibody [JJ09-16]

• Description: Cystatin C is a cysteine (thiol) protease inhibitor that belongs to the type II cystatin gene superfamily and is the most abundant extracellular inhibitor of cysteine proteases. Cystatin C is a constitutively secreted, amyloidogenic protein, which forms a two-fold symmetric dimer and modulates both cysteine protease activity and the expression of class II MHC molecules. Expression of cystatin C is an indicator of kidney function and glomerular filtration rate. Mutations in the cystatin C gene can lead to protein aggregates, which are implicated in hereditary amyloid angiopathy (HCCAA) and cerebral hemorrhage. Although both wild-type and mutant cystatin C are capable of forming concentration dependent inactive dimers, mutant cystatin C dimerizes at lower concentrations and is more susceptible to serine proteases, which may facilitate aggregation. In neuronal cells, oxidative stress stimulates expression of cystatin C, which may positively regulate apoptosis.
• Product Name Alternative: AD 8 antibody AD8 antibody Amyloid angiopathy and cerebral hemorrhage antibody ARMD11 antibody bA218C14.4 (cystatin C) antibody bA218C14.4 antibody Cst 3 antibody Cst3 antibody CST3 protein antibody Cystatin 3 antibody Cystatin-3 antibody Cystatin-C antibody Cystatin3 antibody CystatinC antibody CYTC_HUMAN antibody Epididymis secretory protein Li 2 antibody Gamma trace antibody Gamma-trace antibody HCCAA antibody HEL S 2 antibody MGC117328 antibody Neuroendocrine basic polypeptide antibody Post gamma globulin antibody Post-gamma-globulin antibody
• Abbreviation: CST3
• CAS Number: 9000-83-3
• Swiss Prot: P01034 Human, P21460 Mouse, P14841 Rat
• Cellular Locus: Secreted.
• Host: Rabbit
• Species Reactivity: Human, Mouse, Rat
• Immunogen: Recombinant full length protein of Human Cystatin C aa 1-146 / 146.
• Isotype: IgG
• Conjugation: Non-conjugated
• Type: Recombinant Rabbit monoclonal Antibody
• Applications: WB, IHC-P
• Positive Control: Mouse spleen tissue lysates, human liver carcinoma tissue, human kidney tissue, mouse brain tissue, mouse placenta tissue, mouse kidney tissue.
• Concentration: 1 mg/mL
• Dilution: WB: 1:1,000-1:2,000 ;IHC-P: 1:50-1:200
• Purity: Protein A affinity purified.
• Form: Liquid
• Buffer: 1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
• Molecular Weight: Predicted band size: 16 kDa
• Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
• Recombinant Antibody: Yes