PAX8 Recombinant Rabbit Monoclonal Antibody [JJ08-88]

PAX8 Recombinant Rabbit Monoclonal Antibody [JJ08-88]

• Description: PAX8 is a transcription factor crucial to the organogenesis and development of the thyroid gland, urogenital tract, placenta and inner ear. In the thyroid, PAX8 is a master gene that regulates maintenance of the differentiated thyroid follicular cell phenotype, where it controls and activates the transcription of the main proteins responsible for the functional activity of follicular cells such as thyroglobulin, thyroperoxidase and sodium/iodide symporter. In the developing kidney PAX8 is important for renal vescicle formation. PAX8 regulates the expression of the WT1 gene. PAX8 appears to be currently the most sensitive and specific marker for renal cell carcinoma and ovarian non-mucinous carcinoma. Follicular and papillary thyroid carcinoma are virually always PAX8 positive (while anaplastic carcinoma is positive in most cases and medullary thyroid carcinoma negative). PAX8 is also found in almost all cases of ovarian serous, endometrioid, transitional and clear cell carcinoma (while mucinous carcinoma is positive in a minor number of cases), and endometrial carcinoma.
• Product Name Alternative: OTTHUMP00000158659 antibody OTTHUMP00000158660 antibody OTTHUMP00000203723 antibody OTTHUMP00000203724 antibody Paired box 8 antibody Paired box gene 8 antibody paired box homeotic gene 8 antibody Paired box protein Pax 8 antibody Paired box protein Pax-8 antibody Paired domain gene 8 antibody PAX 8 antibody PAX8 antibody PAX8_HUMAN antibody
• Abbreviation: PAX8
• CAS Number: 9000-83-3
• Swiss Prot: Q06710 Human, Q00288 Mouse, P51974 Rat
• Cellular Locus: Nucleus.
• Host: Rabbit
• Species Reactivity: Human, Mouse, Rat
• Immunogen: Recombinant protein within Human PAX8 aa 101-450 / 450.
• Isotype: IgG
• Conjugation: Non-conjugated
• Type: Recombinant Rabbit monoclonal Antibody
• Applications: WB, IF-Cell, IF-Tissue, IHC-P
• Positive Control: SKOV-3 cell lysates, NIH: OVCAR-3 cell lysates, SKOV-3, NIH:OVCAR-3, human ovarian carcinoma tissue, human thyroid cancer tissue, human thyroid tissue, human kidney tissue, mouse kidney tissue, rat kidney tissue.
• Concentration: 1 mg/mL
• Dilution: WB: 1:1,000 ;IF-Cell: 1:100 ;IF-Tissue: 1:50-1:200 ;IHC-P: 1:500
• Purity: Protein A affinity purified.
• Form: Liquid
• Buffer: 1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
• Molecular Weight: Predicted band size: 48 kDa
• Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
• Recombinant Antibody: Yes