PAX8 Recombinant Mouse Monoclonal Antibody [6G5-R]

PAX8 Recombinant Mouse Monoclonal Antibody [6G5-R]

• Description: The PAX gene family has an important role in the formation of tissues and organs during embryonic development and maintaining the normal function of some cells after birth. The PAX genes give instructions for making proteins that attach themselves to certain areas of DNA. This nuclear protein is involved in thyroid follicular cell development and expression of thyroid-specific genes. PAX8 releases the hormones important for regulating growth, brain development, and metabolism. Also functions in very early stages of kidney organogenesis, the müllerian system, and the thymus. Additionally, PAX8 is expressed in the renal excretory system, epithelial cells of the endocervix, endometrium, ovary, Fallopian tube, seminal vesicle, epididymis, pancreatic islet cells and lymphoid cells. PAX8 and other transcription factors play a role in binding to DNA and regulating the genes that drive thyroid hormone synthesis (Tg, TPO, Slc5a5 and Tshr). This PAX-8 antibody is intended for qualified laboratories to qualitatively identify by light microscopy the presence of associated antigens in sections of formalinfixed, paraffin-embedded tissue sections using IHC test methods.
• Product Name Alternative: OTTHUMP00000158659 antibody OTTHUMP00000158660 antibody OTTHUMP00000203723 antibody OTTHUMP00000203724 antibody Paired box 8 antibody Paired box gene 8 antibody paired box homeotic gene 8 antibody Paired box protein Pax 8 antibody Paired box protein Pax-8 antibody Paired domain gene 8 antibody PAX 8 antibody PAX8 antibody PAX8_HUMAN antibody
• Abbreviation: Pax-8, PAX8
• CAS Number: 9000-83-3
• Swiss Prot: Q06710 Human, Q00288 Mouse
• Cellular Locus: Nucleus.
• Host: Mouse
• Species Reactivity: Human, Mouse, Monkey
• Immunogen: Synthetic peptide corresponding to human PAX8 aa 400-450.
• Isotype: IgG1
• Clone: 6G5-R
• Conjugation: Non-conjugated
• Type: Recombinant Mouse monoclonal Antibody
• Applications: WB, IHC-P, IF-Cell
• Positive Control: NIH:OVCAR-3 cell lysate, COS-1 cell lysate, human kidney tissue, human thyroid cancer tissue, human thyroid tissue, human renal clear cell carcinoma tissue, mouse thyroid tissue, NIH:OVCAR-3.
• Concentration: 1 mg/mL
• Dilution: WB: 1:1,000 ;IHC-P: 1:500-1:2,000 ;IF-Cell: 1:100
• Purity: Protein A affinity purified.
• Form: Liquid
• Buffer: PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
• Molecular Weight: Predicted band size: 48 kDa
• Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
• Recombinant Antibody: Yes