Caspase-5 Recombinant Rabbit Monoclonal Antibody [SD203-2]

• Description:

  Caspases are cysteine proteases which play important roles in the activation of cytokines and in apoptosis. The ICE subfamily of caspases comprises peptides closely related to caspase-1, which promotes maturation of interleukin 1β (IL-1β) and interleukin-18 (IL-18) by proteolytic cleavage of precursor forms to generate biologically active peptides. Both caspase-4 and caspase-5 are members of the caspase-1 subfamily, and are more closely related to each other than to other homologues. Caspase-5 (also designated ICErel-III, TY, ICH-3 and caspase-12 in mouse), can cleave its own precursor, an activity that requires the cysteine 245 residue. Frameshift mutations in caspase-5 have been identified in MMP tumors of the endometrium, colon, and stomach, indicating the caspase-5 may be a new target gene in the microsatellite mutator pathway for cancer. The human caspase 5 gene maps to chromosome 11q22.2-q22.3 and encodes a protein whose expression is barely detectable in most tissues except brain, with highest expression levels being found in lung, liver and skeletal muscle.

• Product Name Alternative:

  Caspase5 Apoptosis related cysteine protease antibody CASP-5 antibody CASP5 antibody CASP5_HUMAN antibody Caspase-5 subunit p10 antibody Caspase-5 antibody Caspase 5 antibody Caspase5 antibody ICE (rel)-III antibody ICERELIII antibody ICH 3 antibody ICH 3 protease antibody Protease ICH-3 antibody Protease TY antibody TY antibody TY protease antibody

• Abbreviation:

  CASP-5, CASP5

• Swiss Prot:

  P51878 Human

• Cellular Locus:

  NLRP1 inflammasome complex, cytoplasm.

• Host:

  Rabbit

• Species Reactivity:

  Human

• Immunogen:

  Synthetic peptide within Human Caspase 5 aa 1-50 / 434.

• Isotype:

  IgG

• Conjugation:

  Non-conjugated

• Type:

  Recombinant Rabbit monoclonal Antibody

• Applications:

  WB, IF-Cell, IF-Tissue, IHC-P, IP

• Positive Control:

  A549, Hela, SHG-44, human liver tissue.

• Concentration:

  1 mg/mL

• Dilution:

  WB: 1:500-1:1,000;IF-Cell: 1:50-1:200;IF-Tissue: 1:50-1:200;IHC-P: 1:50-1:200

• Purity:

  Protein A affinity purified.

• Form:

  Liquid

• Buffer:

  1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

• Molecular Weight:

  Predicted band size: 50 kDa

• Storage Conditions:

  Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

• Recombinant Antibody:

  Yes

• CAS Number:

  9000-83-3