HDAC2 Recombinant Rabbit Monoclonal Antibody [SY29-02]

HDAC2 Recombinant Rabbit Monoclonal Antibody [SY29-02]

• Description: Histone deacetylase 2 (HDAC2) is an enzyme that in humans is encoded by the HDAC2 gene. It belongs to the histone deacetylase class of enzymes responsible for the removal of acetyl groups from lysine residues at the N-terminal region of the core histones (H2A, H2B, H3, and H4). As such, it plays an important role in gene expression by facilitating the formation of transcription repressor complexes and for this reason is often considered an important target for cancer therapy. Though the functional role of the class to which HDAC2 belongs has been carefully studied, the mechanism by which HDAC2 interacts with histone deacetylases of other classes has yet to be elucidated. HDAC2 is broadly regulated by protein kinase 2 (CK2) and protein phosphatase 1 (PP1), but biochemical analysis suggests its regulation is more complex (evinced by the coexistence of HDAC1 and HDAC2 in three distinct protein complexes). HDAC2 has been shown to play a role in cardiac hypertrophy, Alzheimer's disease, Parkinson's disease, acute myeloid leukemia (AML), osteosarcoma, and stomach cancer.
• Product Name Alternative: D10Wsu179e antibody HD 2 antibody HD2 antibody HDAC 2 antibody Hdac2 antibody HDAC2_HUMAN antibody Histone deacetylase 2 (HD2) antibody Histone deacetylase 2 antibody OTTHUMP00000017046 antibody OTTHUMP00000227077 antibody OTTHUMP00000227078 antibody RPD3 antibody transcriptional regulator homolog RPD3 antibody YAF1 antibody YY1 associated factor 1 antibody YY1 transcription factor binding protein antibody Yy1bp antibody
• Abbreviation: HD2, HDAC2
• CAS Number: 9000-83-3
• Swiss Prot: Q92769 Human, P70288 Mouse, F7ENH8 Rat
• Cellular Locus: Nucleus, Cytoplasm.
• Host: Rabbit
• Species Reactivity: Human, Mouse, Rat
• Immunogen: Synthetic peptide within Human HDAC2 aa 439-488 / 488.
• Isotype: IgG
• Conjugation: Non-conjugated
• Type: Recombinant Rabbit monoclonal Antibody
• Applications: WB, IF-Cell, IF-Tissue, IHC-P, IP, FC
• Positive Control: HeLa cell lysate, HEK-293 cell lysate, MCF7 cell lysate, Jurkat cell lysate, L-929 cell lysate, NIH/3T3 cell lysate, C6 cell lysate, HeLa, HEK-293, NIH/3T3, human tonsil tissue, mouse spinal cord tissue, rat spinal cord tissue, C6.
• Concentration: 1 mg/mL
• Dilution: WB: 1:20,000-1:50,000 ;IF-Cell: 1:100-1:1,000 ;IF-Tissue: 1:200-1:1,000 ;IHC-P: 1:6,000 ;FC: 1:1,000 ;IP: Use at an assay dependent concentration.
• Purity: Protein A affinity purified.
• Form: Liquid
• Buffer: 1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
• Molecular Weight: Predicted band size: 55 kDa
• Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
• Recombinant Antibody: Yes