Notch 1 Recombinant Rabbit Monoclonal Antibody [SJ205]

Notch 1 Recombinant Rabbit Monoclonal Antibody [SJ205]

• Description: The LIN-12/notch family of transmembrane receptors is believed to play a central role in development by regulating cell fate decisions. To date, four notch homologs have been identified in mammals and have been designated Notch 1, Notch 2, Notch 3 and Notch 4. The notch genes are expressed in a variety of tissues in both the embryonic and adult organism, suggesting that the genes are involved in multiple signaling pathways. The notch proteins have been found to be overexpressed or rearranged in human tumors. Ligands for notch include Jagged1, Jagged2 and Delta. Jagged can activate notch and prevent myoblast differentiation by inhibiting the expression of muscle regulatory and structural genes. Jagged2 is thought to be involved in the development of various tissues whose development is dependent upon epithelial-mesenchymal interactions. Normal Delta expression is restricted to the adrenal gland and placenta. Delta expression has also been found in neuroendocrine tumors such as neuroblastomas and pheochromocytomas.
• Product Name Alternative: 9930111A19Rik antibody AOS5 antibody AOVD1 antibody hN1 antibody Lin-12 antibody LIN12 antibody Mis6 antibody Motch A antibody mT14 antibody Neurogenic locus notch homolog protein 1 antibody Neurogenic locus notch protein homolog antibody NICD antibody NOTC1_HUMAN antibody Notch 1 antibody Notch 1 intracellular domain antibody NOTCH antibody Notch gene homolog 1 (Drosophila) antibody Notch homolog 1, translocation-associated (Drosophila) antibody NOTCH, Drosophila, homolog of, 1 antibody notch1 antibody TAN1 antibody Translocation associated notch homolog antibody Translocation associated notch protein TAN 1 antibody Translocation-associated notch protein TAN-1 antibody xotch antibody
• Abbreviation: Notch 1, hN1
• CAS Number: 9000-83-3
• Swiss Prot: P46531 Human, Q01705 Mouse
• Cellular Locus: Cell membrane, Nucleus (intracellular domain).
• Host: Rabbit
• Species Reactivity: Human, Mouse, Rat
• Immunogen: Synthetic peptide within Human Notch 1 aa 2,481-2,530 / 2,555.
• Isotype: IgG
• Conjugation: Non-conjugated
• Type: Recombinant Rabbit monoclonal Antibody
• Applications: WB, IF-Cell, IF-Tissue, IHC-P, IP, FC
• Positive Control: MDA-MB-231 cell lysate, THP-1 cell lysate, human pancreas tissue, mouse lung tissue, mouse pancreas tissue, Hela cell.
• Concentration: 1 mg/mL
• Dilution: WB: 1:1,000-1:2,000 ;IF-Cell: 1:50-1:200 ;IF-Tissue: 1:50-1:200 ;IHC-P: 1:50-1:200 ;FC: 1:50-1:100 ;IP: Use at an assay dependent concentration.
• Purity: Protein A affinity purified.
• Form: Liquid
• Buffer: 1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
• Molecular Weight: Predicted band size: 273 kDa
• Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
• Recombinant Antibody: Yes