IFNAR1 Recombinant Rabbit Monoclonal Antibody [SR45-08]

IFNAR1 Recombinant Rabbit Monoclonal Antibody [SR45-08]

• Description: The type I interferons (IFNs), α and β, are a group of structurally and functionally related proteins that are induced by either viruses or double stranded RNA and defined by their ability to confer an antiviral state in cells. The α and β IFNs appear to compete with one another for binding to a common cell surface receptor, while immune IFN (IFNγ) binds to a distinct receptor. The latter protein, IFN-αR, is only weakly responsive to type I interferons in contrast to IFN-α/βR, which binds to and responds effectively to IFN-β and to several of the IFN-? subtypes. Moreover, IFN-α/βR is physically associated with the cytoplasmic tyrosine kinase JAK1 and thus, in addition to ligand binding, appears to be functionally involved in signal transduction. IFN-αR1 is a receptor for IFN-α/β and is present as the full chain (IFN-αR1a) and as a splice-variant (IFN-αR1). The IFN-γ receptor complex consists of an alpha subunit (IFN-γRα) and a beta subunit that is 332 amino acids in length (mouse) and 337 amino acids in length (human).
• Product Name Alternative: Alpha type antiviral protein antibody AVP antibody Beta type antiviral protein antibody CRF2-1 antibody Cytokine receptor class-II member 1 antibody Cytokine receptor family 2 member 1 antibody IFN alpha REC antibody IFN alpha receptor antibody IFN alpha/beta Receptor alpha antibody IFN beta receptor antibody IFN-alpha/beta receptor 1 antibody IFN-R-1 antibody IFNAR antibody Ifnar1 antibody IFNBR antibody IFRC antibody INAR1_HUMAN antibody Interferon (alpha beta and omega) receptor 1 antibody Interferon alpha/beta receptor 1 antibody Interferon alpha/beta receptor alpha chain antibody Interferon beta receptor 1 antibody Type I interferon receptor 1 antibody
• Abbreviation: IFN-R-1, IFN-alpha/beta receptor 1, CRF2-1
• CAS Number: 9000-83-3
• Swiss Prot: P17181 Human, P33896 Mouse, D3ZDS9 Rat
• Cellular Locus: Cell membrane, Late endosome, Lysosome.
• Host: Rabbit
• Species Reactivity: Human, Mouse, Rat
• Immunogen: Synthetic peptide within Human IFNAR1 aa 508-557 / 557.
• Isotype: IgG
• Conjugation: Non-conjugated
• Type: Recombinant Rabbit monoclonal Antibody
• Applications: WB, IHC-P, FC, IP, ICC
• Positive Control: HeLa cell lysate, Jurkat cell lysate, K-562 cell lysate, human tonsil tissue, rat brain tissue, mouse brain tissue, Jurkat.
• Concentration: 1 mg/mL
• Dilution: WB: 1:1,000 ;IHC-P: 1:50-1:200 ;FC: 1:50 ;IP: Use at an assay dependent concentration. ;ICC: 1:100
• Purity: Protein A affinity purified.
• Form: Liquid
• Buffer: 1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
• Molecular Weight: Predicted band size: 64 kDa
• Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
• Recombinant Antibody: Yes